GNH USA

Europe — EMA

Imazol Plus

GNH USA supplies Imazol Plus (Clotrimazole/Hexamidine), a topical antifungal and antiseptic for dermatophytosis, cutaneous candidiasis and superficial skin

Clotrimazole, Hexamidine Diisetionate

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What is Clotrimazole, Hexamidine Diisetionate?

Clotrimazole, the active ingredient in Imazol Plus, is an antifungal presented as a topical formulation for skin use. Together with hexamidine diisetionate, it treats superficial fungal and mixed microbial skin infections in adults and children. GNH USA supplies Imazol Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole, Hexamidine Diisetionate used for?

Imazol Plus is a topical antifungal and antiseptic used for common superficial skin infections. - Dermatophytosis: Reduces fungal growth and alleviates itching, scaling and redness associated with tinea corporis, tinea pedis and related conditions. - Cutaneous candidiasis: Controls Candida overgrowth on the skin, helping to resolve erythema and maceration. - Superficial skin infections: Provides broad‑spectrum antiseptic activity against bacteria and fungi in minor abrasions, intertriginous areas and other mixed‑microbial lesions.

What are the side effects of Clotrimazole, Hexamidine Diisetionate?

Topical application of Imazol Plus may cause local reactions, most of which are mild and self‑limiting.

Common Side Effects: - Burning sensation: transient discomfort at the application site. - Itching: mild pruritus that usually resolves with continued use. - Redness: localized erythema around the treated area. - Dryness: skin may feel less moist after application. - Contact dermatitis: mild allergic skin reaction in sensitive individuals. - Irritation: occasional stinging or tingling.

Serious or Rare Side Effects: - Severe allergic reaction: swelling, hives or difficulty breathing requiring immediate medical attention. - Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare but life‑threatening skin eruptions. - Bullous dermatitis: formation of blisters at the site of application. - Systemic toxicity: extremely rare absorption leading to systemic effects. - Persistent ulceration: non‑healing skin breakdown. - Secondary infection: overgrowth of resistant organisms if used on compromised skin.

What precautions apply to Clotrimazole, Hexamidine Diisetionate?

Before using Imazol Plus, consider the following safety measures. - Pregnancy: consult a healthcare professional before application, as safety data are limited. - Breastfeeding: use with caution; discuss potential exposure with a physician. - Age restriction: not recommended for infants younger than two months without medical advice. - Application area: avoid eyes, mucous membranes and large open wounds. - Allergy: discontinue use immediately if signs of hypersensitivity appear. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Clotrimazole, Hexamidine Diisetionate interact with?

Imazol Plus may interact with other topical agents or systemic medications.

Major Interactions (Avoid): - Concurrent use of other topical antifungal or antiseptic preparations: may increase local irritation or sensitization. - Occlusive dressings over treated area: can enhance absorption and raise risk of adverse skin reactions.

Moderate Interactions (Monitor Closely): - Alcohol‑based skin cleansers: may cause transient stinging when applied before Imazol Plus. - Systemic antifungal therapy (e.g., oral azoles): generally safe but monitor for cumulative irritation. - Other topical corticosteroids: may mask early signs of irritation; observe skin response closely.

Frequently asked questions

What conditions is Imazol Plus used for?+
Imazol Plus is indicated for the topical treatment of dermatophytosis (such as tinea corporis and tinea pedis), cutaneous candidiasis, and other superficial skin infections where both fungal and bacterial organisms may be present.
How does clotrimazole work in Imazol Plus?+
Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to loss of membrane integrity and inhibition of fungal growth.
What is the usual dose of Imazol Plus?+
The dosage regimen for Imazol Plus is determined by the prescribing healthcare professional based on the type and severity of the skin infection, patient age, and treatment response. Patients should follow the prescriber’s instructions precisely.
Is Imazol Plus safe to use during pregnancy or breastfeeding?+
Safety data for Imazol Plus in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.
How do I order Imazol Plus from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.
How does Imazol Plus compare with other topical antifungals?+
Imazol Plus combines clotrimazole, a well‑established azole antifungal, with hexamidine diisetionate, an antiseptic that adds broad‑spectrum antibacterial activity. This dual action can be advantageous over single‑agent antifungals when mixed bacterial‑fungal skin infections are suspected.
What are the recommended storage conditions for Imazol Plus?+
Store Imazol Plus at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and efficacy.
How should I apply Imazol Plus?+
Apply a thin layer of Imazol Plus to the cleaned, dry affected skin area, usually twice daily or as directed by a healthcare professional. Gently rub in until the product is absorbed, and wash hands after application.
What are the most serious risks associated with Imazol Plus?+
Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and bullous dermatitis. Immediate medical attention is required if signs of a severe reaction develop.
Who should not use Imazol Plus?+
Imazol Plus should not be used by individuals with a known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also contraindicated on extensive open wounds, mucous membranes, and in infants under two months without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole, Hexamidine Diisetionate
Route
Cutaneous Use
Manufacturer
Laboratoires Bailleul S.A.
Origin
EU

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