GNH USA

Europe — EMA

Imazol Duo

GNH USA supplies Imazol Duo (Clotrimazole, Hexamidine), a topical antifungal and antibacterial for dermatophytosis, candidiasis and superficial bacterial

Clotrimazole, Hexamidine Diisetionate

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What is Clotrimazole, Hexamidine Diisetionate?

Clotrimazole and Hexamidine diisetionate, the active ingredients in Imazol Duo, are antifungal and antiseptic agents presented as a topical formulation for skin application. They treat fungal infections such as dermatophytosis and candidiasis, as well as superficial bacterial skin infections, in adults and children.

GNH USA supplies Imazol Duo as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole, Hexamidine Diisetionate used for?

Imazol Duo combines an antifungal and an antibacterial agent to treat common superficial skin infections.

- Dermatophytosis (ringworm): Reduces fungal growth and clears skin lesions. - Candidiasis of the skin: Eliminates yeast overgrowth and relieves itching. - Superficial bacterial skin infections: Controls bacterial proliferation and promotes healing.

What are the side effects of Clotrimazole, Hexamidine Diisetionate?

Topical application of Imazol Duo may be associated with local skin reactions.

Common Side Effects: - Mild burning or stinging at the application site. - Itching or mild irritation. - Redness or erythema. - Dryness or peeling of the skin.

Serious or Rare Side Effects: - Severe allergic dermatitis. - Contact urticaria. - Swelling of the face, lips, or tongue. - Blistering or bullous reactions.

What precautions apply to Clotrimazole, Hexamidine Diisetionate?

Use Imazol Duo only as directed and monitor for adverse reactions.

- Avoid use on broken skin: limit application to intact epidermis. - Do not apply to eyes or mucous membranes: avoid accidental contact. - Discontinue if severe irritation occurs: seek medical advice. - Use with caution in patients with known hypersensitivity to clotrimazole or hexamidine: perform a patch test if uncertain. - Pregnancy and lactation: consult a healthcare professional before use. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

What does Clotrimazole, Hexamidine Diisetionate interact with?

Imazol Duo may interact with other topical agents or systemic medications that affect skin integrity or microbial flora.

Major Interactions (Avoid): - Concurrent use with other topical antifungals or antiseptics: may increase irritation risk. - Use with corticosteroid creams: can mask infection signs and delay healing.

Moderate Interactions (Monitor Closely): - Systemic antifungal therapy: may alter local drug absorption. - Antibiotic therapy affecting skin flora: monitor for reduced efficacy. - Use with occlusive dressings: may enhance systemic absorption.

Frequently asked questions

What is Imazol Duo used for?+
Imazol Duo is a topical combination of clotrimazole and hexamidine diisetionate indicated for the treatment of dermatophytosis (ringworm), cutaneous candidiasis, and superficial bacterial skin infections. It is applied directly to the affected skin area to reduce fungal and bacterial growth.
How does clotrimazole work in Imazol Duo?+
Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to cell death and resolution of the infection.
What is the usual dose of Imazol Duo?+
The dosage regimen for Imazol Duo is determined by the prescribing healthcare professional based on the type and severity of the infection, patient age, and skin condition. Typically, a thin layer is applied to the affected area once or twice daily as instructed.
Is Imazol Duo safe during pregnancy or breastfeeding?+
Safety data for Imazol Duo in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using the product to weigh potential benefits against any unknown risks.
How do I order Imazol Duo from GNH USA?+
To order Imazol Duo, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.
How does Imazol Duo compare with other topical antifungal products?+
Imazol Duo offers a dual mechanism by combining an antifungal (clotrimazole) with an antibacterial (hexamidine diisetionate), providing broader coverage than single‑agent antifungal creams. This can be advantageous when mixed fungal‑bacterial skin infections are suspected, whereas standard antifungal-only products lack antibacterial activity.
How should I store Imazol Duo?+
Store Imazol Duo at room temperature, preferably below 25 °C. Keep the tube or container tightly closed, protect it from moisture, direct sunlight, and extreme temperatures to maintain product stability and efficacy.
How is Imazol Duo applied?+
Apply a thin layer of Imazol Duo to clean, dry skin on the affected area. Gently rub it in until it disappears. Follow the prescriber’s instructions regarding frequency and duration of treatment, and avoid covering the area with occlusive dressings unless advised.
What are the most serious risks associated with Imazol Duo?+
Serious risks, although rare, include severe allergic reactions such as contact urticaria, angioedema, or bullous dermatitis. If any signs of swelling, difficulty breathing, or extensive skin blistering occur, discontinue use immediately and seek emergency medical attention.
Who should not use Imazol Duo?+
Imazol Duo should not be used by individuals with a known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also contraindicated on extensive broken skin, mucous membranes, or the eyes.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole, Hexamidine Diisetionate
Route
Cutaneous Use
Manufacturer
Laboratoires Bailleul S.A.
Origin
EU

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