GNH USA

Europe — EMA

Imazol Plus

GNH USA supplies Imazol Plus (Clotrimazole, Hexamidine), a topical antifungal/antiseptic for dermatophyte, candidal and superficial bacterial skin

Clotrimazole, Hexamidine Diisetionate

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What is Clotrimazole, Hexamidine Diisetionate?

Clotrimazole and Hexamidine diisetionate, the active ingredients in Imazol Plus, are antifungal and antiseptic agents presented as a topical formulation for skin use. They are intended for external application to treat fungal and superficial bacterial skin conditions in adults and children. GNH USA supplies Imazol Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole, Hexamidine Diisetionate used for?

Imazol Plus combines antifungal and antiseptic activity to address common superficial skin infections. - Dermatophyte skin infections (e.g., tinea pedis, tinea cruris): reduces fungal growth and relieves itching and scaling. - Candidal skin infections: eradicates superficial Candida species and promotes healing of affected areas. - Superficial bacterial skin infections: provides antiseptic action that limits bacterial colonisation and supports recovery.

What are the side effects of Clotrimazole, Hexamidine Diisetionate?

Imazol Plus is generally well tolerated, but local skin reactions can occur.

Common Side Effects: - Mild burning or stinging at the application site - Itching or mild pruritus - Redness or erythema - Dryness or flaking of the skin - Slight swelling or edema - Contact dermatitis in sensitive individuals

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with difficulty breathing - Swelling of the face, lips, or tongue - Extensive blistering or bullous dermatitis - Necrotic skin lesions or ulceration - Systemic hypersensitivity reactions such as fever or malaise - Persistent or worsening irritation requiring medical attention

What precautions apply to Clotrimazole, Hexamidine Diisetionate?

Before using Imazol Plus, consider the following safety measures. - Avoid use on broken skin: limit application to intact epidermis unless directed by a clinician. - Do not apply to mucous membranes: keep away from eyes, mouth and genital mucosa. - Discontinue if severe irritation occurs: seek medical advice promptly. - Pregnancy and lactation: consult a healthcare professional before use. - Concurrent use with other topical antifungals: assess for additive irritation. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

What does Clotrimazole, Hexamidine Diisetionate interact with?

Imazol Plus may interact with other topical or systemic agents.

Major Interactions (Avoid): - Concurrent use with systemic antifungals: may increase systemic exposure and risk of toxicity. - Use with topical corticosteroids: can reduce antifungal efficacy. - Co‑application with other antiseptic creams containing chlorhexidine: heightened risk of skin irritation.

Moderate Interactions (Monitor Closely): - Use with other skin irritants (e.g., retinoids or alpha‑hydroxy acids): monitor for increased local irritation. - Combination with occlusive dressings: may enhance absorption, watch for local adverse reactions.

Frequently asked questions

What is Imazol Plus used for?+
Imazol Plus is a topical combination of clotrimazole and hexamidine diisetionate indicated for the treatment of superficial fungal infections such as tinea pedis and tinea cruris, candidal skin infections, and mild bacterial skin infections. It works by eliminating the causative organisms and relieving associated symptoms like itching and redness.
How does clotrimazole work in Imazol Plus?+
Clotrimazole interferes with the synthesis of ergosterol, an essential component of fungal cell membranes, by inhibiting the enzyme lanosterol 14‑α‑demethylase. This disruption weakens the membrane, leading to fungal cell death and clearance of the infection from the skin surface.
What is the usual dose of Imazol Plus?+
The dosage regimen for Imazol Plus is determined by the prescribing healthcare professional based on the type and severity of the infection. Typically, a thin layer is applied to the affected area once or twice daily for a period recommended by the clinician.
Is Imazol Plus safe during pregnancy or breastfeeding?+
Safety data for clotrimazole and hexamidine diisetionate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Imazol Plus.
How do I order Imazol Plus from GNH USA?+
To request Imazol Plus, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Imazol Plus compare with other antifungal creams?+
Imazol Plus combines an antifungal (clotrimazole) with an antiseptic (hexamidine diisetionate), offering broader coverage against both fungal and certain bacterial pathogens. Compared with single‑agent antifungal creams, it may reduce the need for additional antibacterial products in mixed infections, though individual response can vary.
How should I store Imazol Plus?+
Store Imazol Plus at room temperature, preferably below 25 °C. Keep the tube or container tightly closed, in its original packaging, and protect it from moisture, direct sunlight and extreme temperatures to maintain product stability.
How is Imazol Plus applied?+
Apply a thin, even layer of Imazol Plus to clean, dry skin on the affected area. Gently rub it in until it disappears. Wash hands before and after application, and avoid contact with eyes, mouth and other mucous membranes.
What are the most serious risks to watch for when using Imazol Plus?+
Serious risks include severe allergic reactions such as anaphylaxis, extensive blistering, swelling of the face or lips, and necrotic skin lesions. If any of these occur, discontinue use immediately and seek emergency medical attention.
Who should not use Imazol Plus?+
Individuals with known hypersensitivity to clotrimazole, hexamidine diisetionate or any excipients in the formulation should avoid using Imazol Plus. It is also contraindicated on extensive broken skin, mucous membranes, or in patients where a healthcare professional advises against its use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole, Hexamidine Diisetionate
Route
Cutaneous Use
Manufacturer
Laboratoires Bailleul S.A.
Origin
EU

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