GNH USA

Europe — EMA

Imazol Plus

GNH USA supplies Imazol Plus (Clotrimazole/Hexamidine), a dermatological anti‑infective for fungal and mixed skin infections. Request a quote for supply.

Clotrimazole, Hexamidine Diisetionate

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What is Clotrimazole, Hexamidine Diisetionate?

Clotrimazole and Hexamidine diisetionate, the active ingredients in Imazol Plus, are antifungal and antiseptic agents presented as a topical formulation for skin use. They are used to treat superficial fungal and mixed fungal‑bacterial skin infections in adults and children when appropriate. GNH USA supplies Imazol Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole, Hexamidine Diisetionate used for?

Imazol Plus acts on superficial dermatological infections caused by fungi and mixed microbial flora. - Dermatophyte infections (e.g., tinea corporis, tinea cruris): Reduces fungal growth and alleviates lesion symptoms. - Candidal skin infections: Inhibits Candida proliferation and promotes healing of affected areas. - Mixed fungal‑bacterial skin infections: Provides combined antifungal and antiseptic activity to control both pathogen types. - Superficial cutaneous mycoses: Helps clear infection and prevent recurrence when applied as directed.

What are the side effects of Clotrimazole, Hexamidine Diisetionate?

Imazol Plus may cause local skin reactions, most of which are mild and self‑limiting.

Common Side Effects: - Mild burning or stinging at the application site - Itching or pruritus - Redness or erythema - Dryness or flaking of the skin - Slight swelling or edema - Contact dermatitis

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Extensive skin ulceration or necrosis - Bullous or vesicular dermatitis - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Systemic hypersensitivity with fever or malaise - Severe edema or angioedema

What precautions apply to Clotrimazole, Hexamidine Diisetionate?

Before using Imazol Plus, consider the following precautions. - Pregnancy: Safety not established; use only if benefits outweigh potential risks. - Breastfeeding: Unknown safety; evaluate risk versus benefit with a healthcare professional. - Age: Not recommended for children under 2 years unless specifically prescribed. - Skin condition: Avoid application on extensive damaged skin, mucous membranes, or severe burns. - Concomitant topical agents: Do not combine with other irritant or sensitizing products without medical advice. - Store at ambient temperature: Keep in original container, protect from moisture and direct sunlight.

What does Clotrimazole, Hexamidine Diisetionate interact with?

Imazol Plus may interact with other topical or systemic agents.

Major Interactions (Avoid): - Concurrent use with other azole antifungal creams: May increase local irritation. - Combination with systemic antifungals metabolized by CYP450 enzymes: Potential additive toxicity. - Co‑application with potent topical corticosteroids: May mask infection signs and delay healing.

Moderate Interactions (Monitor Closely): - Use with skin sensitizers or allergens: Monitor for heightened allergic responses. - Application under occlusive dressings: May increase drug absorption and local irritation.

Frequently asked questions

What is Imazol Plus used for?+
Imazol Plus is a topical combination of clotrimazole and hexamidine diisetionate indicated for the treatment of superficial fungal infections such as tinea corporis and tinea cruris, candidal skin infections, and mixed fungal‑bacterial skin infections. It is applied to the affected skin area to reduce microbial growth and relieve symptoms.
How does clotrimazole work?+
Clotrimazole inhibits fungal ergosterol synthesis by blocking the enzyme lanosterol 14α‑demethylase, which is essential for fungal cell membrane formation. This disruption compromises membrane integrity, leading to fungal cell death. Hexamidine diisetionate adds broad‑spectrum antiseptic activity by disrupting microbial cell membranes.
What is the usual dose?+
The dosing regimen for Imazol Plus is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and the area of skin involved. Typically, a thin layer is applied to the affected area once or twice daily for the period recommended by the prescriber.
Is Imazol Plus safe in pregnancy or breastfeeding?+
Safety data for clotrimazole and hexamidine diisetionate during pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.
How do I order Imazol Plus from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.
How does Imazol Plus compare with other antifungal creams?+
Compared with single‑agent azole creams, Imazol Plus combines an azole (clotrimazole) with an antiseptic (hexamidine diisetionate), offering both antifungal and antibacterial activity. This dual mechanism can be advantageous in mixed infections, whereas monotherapy may be insufficient when bacterial colonisation co‑exists.
What are the storage and handling requirements?+
Imazol Plus should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and heat sources. Ensure the container is tightly closed when not in use to maintain product stability.
How is Imazol Plus administered?+
Imazol Plus is a topical preparation applied directly to clean, dry skin. A thin layer is spread over the affected area, gently massaged until absorbed. The frequency and duration of treatment are set by the prescriber, and hands should be washed before and after application.
What are the most serious risks to watch for?+
Although rare, serious adverse reactions may include severe skin irritation, allergic dermatitis, bullous eruptions, or systemic hypersensitivity such as anaphylaxis. Patients should discontinue use and seek immediate medical attention if they experience extensive redness, swelling, blistering, or signs of an allergic reaction.
Who should not use Imazol Plus?+
Imazol Plus should be avoided in individuals with known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also not recommended for use on extensive damaged skin, mucous membranes, or in patients where the safety profile in pregnancy and lactation has not been established without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Clotrimazole, Hexamidine Diisetionate
Route
Cutaneous Use
Manufacturer
Laboratoires Bailleul S.A.
Origin
EU

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