GNH USA

Europe — EMA

Oftan Dexa-Chlora (Chloramphenicol, Dexamethasone)

GNH USA supplies Oftan Dexa-Chloro (Chloramphenicol/Dexamethasone), a topical antibiotic/anti‑inflammatory for bacterial eye infections and post‑operative

Chloramphenicol, Dexamethasone

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What is Chloramphenicol, Dexamethasone?

Chloramphenicol, the active ingredient in Oftan Dexa-Chloro, is an antibiotic and anti‑inflammatory agent presented as a topical ophthalmic suspension for ocular use. It treats bacterial eye infections and reduces inflammation in the eye. GNH USA supplies Oftan Dexa‑Chloro as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Oftan Dexa‑Chloro as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Chloramphenicol, Dexamethasone used for?

Oftan Dexa‑Chloro combines chloramphenicol and dexamethasone to address bacterial and inflammatory ocular conditions.

- Bacterial conjunctivitis: reduces bacterial load and resolves infection symptoms. - Post‑operative eye inflammation: diminishes swelling and discomfort after eye surgery. - Allergic keratoconjunctivitis: controls inflammation and relieves itching and redness. - Corneal ulcer prophylaxis: helps prevent secondary bacterial infection in compromised corneas. - Traumatic eye injury: limits inflammation and infection risk in ocular trauma.

What are the side effects of Chloramphenicol, Dexamethasone?

Oftan Dexa‑Chloro may cause local and systemic adverse reactions, although many patients tolerate it well.

Common Side Effects: - Burning or stinging sensation on instillation. - Temporary blurred vision. - Mild ocular irritation or redness. - Foreign‑body sensation. - Mild eyelid edema.

Serious or Rare Side Effects: - Allergic contact dermatitis. - Secondary ocular infection with resistant organisms. - Increased intra‑ocular pressure. - Corneal thinning or ulceration. - Systemic bone‑marrow suppression (rare with extensive use). - Vision loss due to severe inflammation or infection.

What precautions apply to Chloramphenicol, Dexamethasone?

When using Oftan Dexa‑Chloro, follow safety guidelines to minimize risks.

- Indications review: confirm bacterial infection and need for steroid therapy. - Duration limit: avoid prolonged use beyond prescribed period. - Monitor IOP: check intra‑ocular pressure in patients at risk of glaucoma. - Systemic absorption: caution in patients with known chloramphenicol hypersensitivity. - Pregnancy & lactation: use only if clearly needed, after risk‑benefit assessment. - Store at room temperature: keep in the original container, protect from light and moisture.

What does Chloramphenicol, Dexamethasone interact with?

Oftan Dexa‑Chloro can interact with other ophthalmic agents and systemic drugs.

Major Interactions (Avoid): - Concurrent use of other topical corticosteroids: may amplify steroid‑related side effects. - Systemic chloramphenicol: increases risk of bone‑marrow toxicity.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory eye drops: may affect healing. - Antiviral eye preparations (e.g., acyclovir): monitor for reduced efficacy. - Antifungal eye drops: assess for potential antagonism. - Contact lens wear: may retain drug residues, increasing exposure. - Systemic immunosuppressants: watch for heightened infection risk.

Frequently asked questions

What is Oftan Dexa‑Chloro used for?+
Oftan Dexa‑Chloro is a combination eye drop that treats bacterial eye infections and reduces inflammation. It is commonly prescribed for conditions such as bacterial conjunctivitis, post‑operative ocular inflammation, allergic keratoconjunctivitis, and to prevent infection in corneal injuries.
How does chloramphenicol work in Oftan Dexa‑Chloro?+
Chloramphenicol blocks bacterial protein synthesis by binding to the 50S ribosomal subunit, which stops bacterial growth. This antimicrobial action helps clear the infection while dexamethasone simultaneously suppresses the inflammatory response.
What is the usual dose of Oftan Dexa‑Chloro?+
The dosing regimen for Oftan Dexa‑Chloro is determined by the prescribing clinician based on the specific ocular condition, severity, and patient factors. The prescriber will indicate the number of drops and frequency appropriate for each case.
Is Oftan Dexa‑Chloro safe during pregnancy or breastfeeding?+
Use of Oftan Dexa‑Chloro during pregnancy or lactation should only occur when the potential benefit justifies any potential risk to the fetus or infant. The decision must be made by a qualified healthcare professional after a careful risk‑benefit assessment.
How do I order Oftan Dexa‑Chloro from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Oftan Dexa‑Chloro compare with other ocular antibiotics?+
Compared with single‑agent eye drops, the chloramphenicol‑dexamethasone combo offers both antimicrobial and anti‑inflammatory actions in one formulation, which can simplify treatment regimens. However, steroid‑containing products require careful monitoring for intra‑ocular pressure and infection risk, unlike non‑steroidal antibiotics.
What are the storage requirements for Oftan Dexa‑Chloro?+
Store at room temperature, ideally below 25 °C, in the original container. Protect the suspension from light, moisture and extreme temperature fluctuations to maintain stability and potency.
How is Oftan Dexa‑Chloro administered?+
The product is applied as an ophthalmic suspension. The patient instills the prescribed number of drops into the affected eye(s) using aseptic technique, typically avoiding contact of the dropper tip with the ocular surface or eyelashes.
What are the most serious risks associated with Oftan Dexa‑Chloro?+
Serious risks include allergic reactions, secondary ocular infections with resistant organisms, increased intra‑ocular pressure, and, rarely, systemic bone‑marrow suppression from chloramphenicol absorption. Prompt medical attention is required if any severe symptoms develop.
Who should not use Oftan Dexa‑Chloro?+
Patients with known hypersensitivity to chloramphenicol, dexamethasone, or any formulation excipients should avoid the product. It is also contraindicated in viral ocular infections such as herpes simplex keratitis, where steroids may worsen the disease.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Chloramphenicol, Dexamethasone
Route
Ocular Use
Manufacturer
Santen Oy
Origin
EU

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