Oftan Dexa-Chlora (Chloramphenicol, Dexamethasone)

Chloramphenicol and Dexamethasone, the active ingredients in Oftan Dexa-Chlora, are an antibiotic and a corticosteroid presented as an ophthalmic suspension for ocular use. It treats bacterial eye infections and inflammatory ocular conditions.

GNH USA supplies Oftan Dexa-Chlora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Oftan Dexa-Chlora combines an antibiotic and a corticosteroid to manage bacterial and inflammatory eye disorders. - Bacterial conjunctivitis: reduces bacterial load and associated inflammation. - Keratitis: eradicates causative bacteria while controlling corneal inflammation. - Post‑operative ocular inflammation: limits swelling and prevents infection after eye surgery. - Anterior uveitis: suppresses intra‑ocular inflammation and treats secondary bacterial involvement.

Adverse reactions may occur with ocular use of this combination product.

Common Side Effects: - Stinging or burning sensation on instillation. - Transient blurred vision. - Conjunctival hyperemia. - Increased tearing. - Mild ocular irritation.

Serious or Rare Side Effects: - Allergic contact dermatitis or severe hypersensitivity. - Secondary ocular infection or corneal ulceration. - Elevated intra‑ocular pressure leading to glaucoma. - Cataract formation with prolonged use. - Systemic bone‑marrow suppression (rare with extensive absorption).

Before prescribing, clinicians should consider safety aspects specific to ocular corticosteroid‑antibiotic combinations. - Allergy assessment: avoid if known hypersensitivity to chloramphenicol, dexamethasone, or excipients. - Duration of therapy: limit use to the shortest effective period to reduce risk of cataract or glaucoma. - Monitoring: assess intra‑ocular pressure periodically during prolonged treatment. - Pregnancy and lactation: use only if potential benefit outweighs risk; data are limited. - Pediatric use: exercise caution, especially in neonates, due to systemic absorption concerns. - Store at room temperature: keep in original container, protect from light and moisture.

Oftan Dexa-Chlora may interact with systemic or topical agents that affect ocular pressure or bone‑marrow function.

Major Interactions (Avoid): - Systemic corticosteroids: additive risk of intra‑ocular hypertension. - Systemic chloramphenicol: increased potential for bone‑marrow suppression. - Other topical steroids: cumulative effect on intra‑ocular pressure. - MAO inhibitors: possible enhancement of chloramphenicol toxicity. - Antifungal agents (e.g., azoles): may alter ocular drug metabolism.

Moderate Interactions (Monitor Closely): - Topical non‑steroidal anti‑inflammatory drugs: may increase ocular irritation. - Antihistamine eye drops: could reduce drug absorption. - Systemic immunosuppressants: monitor for infection risk.