GNH USA

Europe — EMA

Nicorandil Zentiva

GNH USA supplies Nicorandil Zentiva (Nicorandil), a vasodilator for angina pectoris. Request a quote for global supply to hospitals, pharmacies and clinics

Nicorandil

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1
Pack/s

What is Nicorandil?

Nicorandil, the active ingredient in Nicorandil Zentiva, is a potassium channel activator/vasodilator presented as an oral dosage form for oral use. It is used to treat angina pectoris in adult patients.

GNH USA supplies Nicorandil Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nicorandil used for?

Nicorandil is indicated for conditions involving myocardial ischemia and related chest pain.

- Angina pectoris: reduces frequency of chest pain episodes by improving coronary blood flow.

What are the side effects of Nicorandil?

Nicorandil may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects: - Headache: mild to moderate headache reported. - Flushing: transient facial flushing. - Dizziness: occasional sensation of light‑headedness. - Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Angina worsening: paradoxical increase in chest pain. - Allergic reactions: rash, urticaria, or anaphylaxis. - Gastro‑intestinal ulceration: rare but serious ulcer formation.

What precautions apply to Nicorandil?

When prescribing Nicorandil, clinicians should consider the following precautions.

- Cardiovascular disease: monitor blood pressure and heart rate closely. - Renal impairment: use with caution and adjust dosing as needed. - Hepatic dysfunction: assess liver function before initiation. - Concomitant vasodilators: increased risk of hypotension. - Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk. - Store at room temperature below 25°C: keep in original container, protect from moisture.

What does Nicorandil interact with?

Nicorandil can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Nitrates (e.g., nitroglycerin): additive vasodilation may cause severe hypotension. - Sildenafil or other PDE‑5 inhibitors: risk of profound blood pressure fall. - Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may enhance hypotensive effect.

Moderate Interactions (Monitor Closely): - Diuretics: may increase risk of electrolyte imbalance. - Calcium channel blockers: additive effect on vascular tone. - Antiplatelet drugs: potential for increased bleeding risk.

Frequently asked questions

What is Nicorandil Zentiva used for?+
Nicorandil Zentiva is used to relieve episodes of angina pectoris, a type of chest pain caused by reduced blood flow to the heart muscle. It works by widening coronary arteries and decreasing the workload on the heart, helping to improve oxygen delivery during periods of increased demand.
How does nicorandil work in the body?+
Nicorandil combines two mechanisms: it releases nitric oxide, which relaxes vascular smooth muscle, and it opens ATP‑sensitive potassium channels, leading to hyperpolarisation of the cell membrane. Together these actions cause dilation of coronary vessels and lower systemic vascular resistance, reducing both preload and afterload.
What is the usual dose of Nicorandil Zentiva?+
The appropriate dose of Nicorandil Zentiva is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Dosage adjustments are made individually, and patients should follow the specific instructions provided by their healthcare professional.
Is Nicorandil safe during pregnancy or breastfeeding?+
Safety data for nicorandil in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.
How do I order Nicorandil Zentiva from GNH USA?+
To request Nicorandil Zentiva, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nicorandil compare with other anti‑anginal drugs?+
Nicorandil differs from traditional nitrates and beta‑blockers by simultaneously donating nitric oxide and activating potassium channels, offering both arterial and venous dilation. This dual action can provide symptom relief in patients who are intolerant to or have insufficient response to single‑mechanism agents.
What are the storage requirements for Nicorandil Zentiva?+
Nicorandil Zentiva should be stored at room temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Nicorandil Zentiva administered?+
Nicorandil Zentiva is taken orally, usually with or without food as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.
What are the most serious risks associated with Nicorandil?+
The most serious risks include severe hypotension, which can lead to dizziness, fainting or shock, and rare cases of gastrointestinal ulceration. Patients should seek immediate medical attention if they experience sudden drops in blood pressure, worsening chest pain, or signs of an allergic reaction.
Who should not use Nicorandil Zentiva?+
Nicorandil is contraindicated in patients with known hypersensitivity to nicorandil or any of its excipients, and it should be avoided in individuals with severe hypotension, recent myocardial infarction, or uncontrolled heart failure unless specifically advised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nicorandil
Route
Oral Use
Manufacturer
Zentiva Pharma Uk Limited
Origin
EU

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