Ikorel

Nicorandil, the active ingredient in Ikorel, is a potassium channel activator presented as an oral dosage form for oral use. It is used to treat stable angina pectoris in adult patients. GNH USA supplies Ikorel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ikorel, a potassium channel activator, is indicated for conditions involving myocardial oxygen demand and supply mismatch. - Stable angina pectoris: improves exercise tolerance and reduces frequency of angina attacks.

Nicorandil may cause a range of adverse reactions.

Common Side Effects: - Headache: mild to moderate pressure sensation. - Flushing: transient warmth and redness of skin. - Dizziness: sensation of light‑headedness, especially on standing. - Nausea: mild stomach upset. - Palpitations: awareness of heartbeats. - Hypotension: low blood pressure, often orthostatic.

Serious or Rare Side Effects: - Gastro‑intestinal ulceration: painful sores in mouth, esophagus or stomach. - Severe hypotension: marked drop in blood pressure requiring medical attention. - Stevens‑Johnson syndrome: rare severe skin reaction. - Myocardial infarction: rare worsening of heart ischemia. - Anaphylaxis: acute allergic reaction. - Hepatic dysfunction: abnormal liver enzyme elevations.

Before initiating therapy, consider the following safety measures. - Blood pressure monitoring: check baseline and periodic readings. - Ulcer assessment: evaluate for existing gastrointestinal lesions. - Hepatic function: assess liver enzymes in patients with liver disease. - Concomitant vasodilators: use caution with other blood‑pressure‑lowering agents. - Severe hypotension: avoid in patients with markedly low blood pressure. - Store at below 25°C: keep in the original pack, protect from moisture.

Nicorandil can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid): - Nitrates: additive vasodilation may cause severe hypotension. - Phosphodiesterase‑5 inhibitors: risk of profound blood pressure fall. - Other potassium channel openers: increased risk of hypotension.

Moderate Interactions (Monitor Closely): - Antihypertensives (e.g., ACE inhibitors, beta‑blockers): may enhance blood pressure lowering. - Diuretics: potential for electrolyte imbalance and hypotension. - Alcohol: can potentiate vasodilatory effects.