Europe — EMA
Nicorandil Generics [uk] Ltd
GNH USA supplies Nicorandil Generics (Nicorandil), a vasodilator antianginal for chronic stable angina. Request a quote for global supply to meet your needs.
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What is Nicorandil?
Nicorandil, the active ingredient in Nicorandil Generics [uk] Ltd, is a vasodilator (potassium channel opener) presented as an oral formulation for oral use. It is used to relieve chest pain in patients with chronic stable angina by opening ATP‑sensitive potassium channels and releasing nitric oxide, which improves coronary blood flow and reduces myocardial oxygen demand.
GNH USA supplies Nicorandil Generics [uk] Ltd as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Nicorandil used for?
Nicorandil is an antianginal vasodilator used in the management of coronary artery disease.
Chronic stable angina: reduces the frequency and severity of angina attacks. Refractory angina: provides symptom relief when other therapies are insufficient. Angina pectoris: improves exercise tolerance by enhancing myocardial perfusion. Ischemic heart disease: helps control chest pain associated with reduced coronary flow.
What are the side effects of Nicorandil?
Nicorandil may cause a range of adverse reactions, which are categorised by frequency and severity.
Common Side Effects: - Headache - Flushing - Dizziness - Nausea
Serious or Rare Side Effects: - Gastrointestinal ulceration - Severe hypotension
What precautions apply to Nicorandil?
Before initiating Nicorandil therapy, consider the following precautions.
Cardiovascular assessment: evaluate blood pressure and heart rate. Renal impairment: use with caution in severe renal dysfunction. Hepatic impairment: monitor liver function and adjust if necessary. Concomitant nitrates: avoid combined use due to additive hypotensive effects. Pregnancy and lactation: safety not established; avoid unless essential. Store at ambient temperature: keep in the original pack, protect from moisture.
What does Nicorandil interact with?
Nicorandil can interact with several drug classes; monitor patients accordingly.
Major Interactions (Avoid): - Nitrates: combined use may cause profound hypotension. - PDE5 inhibitors: risk of severe blood pressure reduction.
Moderate Interactions (Monitor Closely): - Diuretics: may enhance hypotensive effect. - Beta‑blockers: may require blood pressure monitoring. - Calcium channel blockers: potential additive vasodilatory effect.
