Metoxsalene S.A.L.F.

Methoxsalen, the active ingredient in Metoxsalene S.A.L.F., is a psoralen presented as a sterile solution for extracorporeal use. It is employed in PUVA therapy to treat chronic skin disorders such as psoriasis and vitiligo in adult patients.

GNH USA supplies Metoxsalene S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Methoxsalen is used in dermatologic conditions that respond to PUVA therapy, targeting abnormal skin cell proliferation and depigmentation. - Psoriasis: reduces scaling, erythema and plaque thickness. - Vitiligo: promotes repigmentation of depigmented patches. - Cutaneous T‑cell lymphoma: used as part of PUVA protocols to control skin lesions.

Methoxsalen may cause a range of adverse reactions, from mild to severe, depending on exposure and patient factors.

Common Side Effects: - Nausea: transient gastrointestinal upset after administration. - Headache: mild to moderate intensity during treatment. - Erythema: redness of skin at treated sites. - Itching: pruritus associated with phototoxic reaction. - Hyperpigmentation: darkening of exposed skin areas. - Phototoxicity: heightened skin sensitivity to UVA.

Serious or Rare Side Effects: - Severe burns: deep skin injury from excessive UVA exposure. - Blistering: formation of fluid‑filled lesions on irradiated skin. - Cutaneous malignancies: increased risk of skin cancer with long‑term use. - Ocular cataracts: lens opacity from systemic exposure. - Hemolysis in G6PD deficiency: rapid destruction of red blood cells. - Systemic hypersensitivity: rare allergic reactions requiring medical attention.

Methoxsalen requires careful patient assessment and monitoring to minimize risks. - Assess skin type: evaluate for high phototype or history of skin cancer. - Avoid excessive UVA: limit exposure time and intensity during PUVA sessions. - Monitor ocular health: schedule regular eye examinations for cataract detection. - Check G6PD status: contraindicated in patients with glucose‑6‑phosphate dehydrogenase deficiency. - Store at ambient temperature: keep below 25°C, in original packaging, protected from moisture and light.

Methoxsalen can interact with other agents that influence photosensitivity or coagulation.

Major Interactions (Avoid): - Azathioprine: additive immunosuppression may increase infection risk. - Cyclosporine: combined phototoxic effects can exacerbate skin damage. - Retinoids (e.g., acitretin): heightened photosensitivity and mucocutaneous toxicity.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in efficacy due to hepatic enzyme induction. - Antifungal azoles (e.g., ketoconazole): may alter methoxsalen metabolism. - Anticoagulants (e.g., warfarin): monitor INR as phototherapy can affect vitamin K levels.