Meladinine

Methoxsalen, the active ingredient in Meladinine, is a psoralen presented as a topical formulation for skin use. It is employed in the management of certain pigmentary and proliferative skin disorders, primarily in adult patients. GNH USA supplies Meladinine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Methoxsalen acts as a photosensitizing agent used in dermatology to modify disease activity in light‑dependent therapies. - Vitiligo: promotes repigmentation of depigmented patches when combined with UVA exposure. - Psoriasis: reduces scaling and erythema of plaques as part of PUVA treatment. - PUVA adjunct therapy: enhances therapeutic response in selected skin conditions requiring UVA phototherapy.

Methoxsalen may cause a range of skin‑related and systemic reactions.

Common Side Effects: - Erythema: redness of the treated skin area. - Pruritus: itching at the application site. - Burning sensation: transient discomfort during UVA exposure. - Hyperpigmentation: darkening of treated skin. - Headache: mild to moderate intensity. - Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects: - Blistering: formation of vesicles or bullae on exposed skin. - Severe photosensitivity: exaggerated skin reaction to light. - Cutaneous squamous cell carcinoma: potential long‑term risk with extensive use. - Systemic toxicity: rare hepatic or renal effects. - Anaphylaxis: extremely rare hypersensitivity reaction.

When using Methoxsalen, several safety measures should be observed. - Sun exposure: avoid direct sunlight on treated areas for at least 24 hours after application. - Protective eyewear: wear UVA‑blocking glasses during phototherapy sessions. - Concomitant photosensitizers: do not use other photosensitizing drugs simultaneously. - Skin monitoring: inspect treated skin regularly for abnormal reactions. - Pregnancy: safety not established; avoid use unless clearly indicated. - Store at room temperature: keep in the original container, protect from light and moisture.

Methoxsalen can interact with other medications that affect photosensitivity or skin healing.

Major Interactions (Avoid): - Tetracyclines: increase risk of severe photosensitivity. - Thiazide diuretics: potentiate phototoxic reactions. - Retinoids: heighten skin irritation and erythema.

Moderate Interactions (Monitor Closely): - NSAIDs: may modestly increase photosensitivity. - Antifungal agents (e.g., ketoconazole): possible additive skin effects. - Oral contraceptives: monitor for enhanced photosensitivity.