Methoxsalen G.L. Pharma

Methoxsalen, the active ingredient in Methoxsalen G.L. Pharma, is a Psoralen presented as a solution for extracorporeal use. It is employed in PUVA therapy to treat psoriasis, vitiligo, cutaneous T‑cell lymphoma and to support extracorporeal photopheresis for graft‑versus‑host disease.

GNH USA supplies Methoxsalen G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Methoxsalen is a photosensitizing agent used in PUVA‑based treatment protocols for several dermatologic and hematologic conditions.

- Psoriasis: improves skin lesions when combined with UVA exposure. - Vitiligo: promotes repigmentation through controlled phototherapy. - Cutaneous T‑cell lymphoma (mycosis fungoides): assists disease control in PUVA regimens. - Extracorporeal photopheresis for graft‑versus‑host disease: facilitates immune modulation during treatment.

Methoxsalen may cause a range of adverse reactions, from mild to severe, depending on exposure and individual susceptibility.

Common Side Effects: - Nausea and vomiting - Headache - Transient erythema or redness of treated skin - Pruritus (itching) - Phototoxic skin reactions limited to exposed areas - Mild fatigue

Serious or Rare Side Effects: - Severe phototoxic burns or blistering - Leukopenia or other blood dyscrasias - Hepatic dysfunction or elevated liver enzymes - Severe nausea/vomiting requiring medical attention - Anaphylactic reactions (rare) - Persistent hyperpigmentation of skin

Methoxsalen requires careful handling and patient monitoring due to its photosensitizing properties. - Pregnancy: Category D – avoid unless benefits outweigh risks. - Breastfeeding: Not recommended; methoxsalen may be excreted in milk. - Renal or hepatic impairment: Monitor liver and kidney function tests regularly. - Sunlight exposure: Advise patients to avoid direct sunlight and use protective clothing. - Concomitant photosensitizing drugs: Use with caution and adjust phototherapy protocols. - Store at below 25°C: keep in the original container, protect from moisture and light.

Methoxsalen can interact with several drug classes, influencing its safety and efficacy.

Major Interactions (Avoid): - Azathioprine - Cyclosporine - Other psoralen compounds - Tetracycline antibiotics - Oral retinoids (e.g., isotretinoin)

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs) - Anticoagulants (e.g., warfarin) - Diuretics - Oral contraceptives - Antifungal agents (e.g., ketoconazole)