Melaoline

Methoxsalen, the active ingredient in Melaoline, is a psoralen presented as an oral tablet for oral use. It is employed as a dermatologic photosensitizer to treat conditions such as psoriasis and vitiligo in adult patients. GNH USA supplies Melaoline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Methoxsalen is used as a photosensitizing agent in dermatologic disorders that respond to UVA‑mediated therapy. - Psoriasis: reduces epidermal hyperplasia and scaling, improving plaque appearance. - Vitiligo: promotes repigmentation of depigmented skin areas when combined with controlled UVA exposure.

Methoxsalen may cause a range of adverse reactions, ranging from mild to severe, especially when combined with UVA exposure.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Headache: transient cranial discomfort. - Photosensitivity reactions: increased skin sensitivity to light. - Mild erythema: redness of exposed skin. - Pruritus: itching at treated sites. - Gastrointestinal upset: occasional vomiting or abdominal discomfort.

Serious or Rare Side Effects: - Severe phototoxic burns: blistering and ulceration of skin. - Hepatotoxicity: elevated liver enzymes requiring monitoring. - Hemolytic anemia: especially in patients with G6PD deficiency. - Cardiac arrhythmias: rare but reported with high systemic exposure. - Severe nausea/vomiting: may require medical intervention. - Secondary malignancies: theoretical risk with prolonged use.

Methoxsalen therapy requires careful patient assessment and monitoring to minimize risks. - Assess liver function: obtain baseline hepatic enzymes before initiation. - Avoid excessive sun exposure: advise protective clothing and sunscreen. - Review concomitant photosensitizing drugs: identify and adjust other agents that increase light sensitivity. - Use contraception: advise women of reproductive potential to avoid pregnancy during treatment. - Monitor blood counts: periodic CBC to detect hemolysis or anemia. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct light.

Methoxsalen can interact with several drug classes, influencing safety and efficacy.

Major Interactions (Avoid): - Concurrent psoralen or UVA therapy: may cause excessive phototoxicity. - Strong CYP450 inhibitors (e.g., ketoconazole): increase systemic exposure. - Anticoagulants (e.g., warfarin): heightened risk of bleeding.

Moderate Interactions (Monitor Closely): - Photosensitizing antibiotics (tetracyclines, fluoroquinolones): may amplify skin reactions. - Retinoids (isotretinoin): potential for increased skin irritation. - Diuretics (thiazides): may enhance photosensitivity. - Oral contraceptives: monitor for altered efficacy. - Antihistamines: possible additive sedation.