Metoxsalene G.L. Pharma

Methoxsalen, the active ingredient in Metoxsalene, is a psoralen presented as a pharmaceutical preparation for extracorporeal use. It is employed in the management of certain chronic skin disorders and is prescribed by qualified healthcare professionals.

GNH USA supplies Metoxsalene as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Methoxsalen is used in dermatologic conditions that respond to psoralen‑UVA (PUVA) therapy. - Psoriasis: reduces plaque formation and scaling by inhibiting keratinocyte proliferation. - Vitiligo: promotes repigmentation of depigmented patches through melanocyte stimulation. - Cutaneous T‑cell lymphoma: controls skin lesions by suppressing malignant T‑cell growth.

Methoxsalen may cause a range of adverse reactions, most of which are related to its photosensitizing properties.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset after oral administration. - Headache: transient cranial discomfort. - Erythema: mild skin reddening after UVA exposure. - Pruritus: itching of treated skin areas. - Hyperpigmentation: darkening of skin in exposed zones.

Serious or Rare Side Effects: - Severe phototoxic reactions: blistering or ulceration of skin. - Cutaneous malignancies: increased risk of skin cancer with prolonged use. - Hepatic toxicity: abnormal liver function tests. - Anaphylaxis: rare systemic allergic response. - Persistent photodermatitis: chronic skin sensitivity to light.

Methoxsalen requires careful patient assessment and monitoring before and during therapy. - Pregnancy: contraindicated (Category X) due to teratogenic risk; avoid use in pregnant patients. - Breastfeeding: not recommended as drug may be excreted in milk. - UV exposure: limit UVA exposure to prescribed intervals to reduce phototoxicity. - Liver function: assess hepatic status before initiation and periodically thereafter. - Eye protection: use protective eyewear during UVA treatment to prevent cataract formation. - Store below 25°C: keep in original packaging, protect from moisture and light.

Methoxsalen can alter the activity of several concomitant medications, necessitating vigilance.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect, risk of bleeding. - Azathioprine: enhanced immunosuppression, potential bone marrow toxicity. - Other photosensitizers (e.g., tetracyclines, retinoids): additive phototoxic risk.

Moderate Interactions (Monitor Closely): - Oral contraceptives: reduced efficacy, consider alternative contraception. - Antihistamines: possible increased sedation. - Diuretics: monitor electrolyte balance. - Antidepressants (SSRIs): watch for serotonin syndrome signs when combined with other serotonergic agents.