Methoxsalene G.L. Pharma

Methoxsalen, the active ingredient in Methoxsalene G.L. Pharma, is a psoralen presented as a solution for extracorporeal use. It is employed in photochemotherapy to treat psoriasis, vitiligo and cutaneous T‑cell lymphoma in adult patients.

GNH USA supplies Methoxsalene G.L. Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Methoxsalen is a psoralen used in photochemotherapy for several dermatologic conditions. - Psoriasis: improves skin lesions by reducing hyperproliferation of keratinocytes. - Vitiligo: promotes repigmentation by stimulating melanocyte activity. - Cutaneous T‑cell lymphoma: helps control malignant skin infiltrates through immunosuppression.

Methoxsalen may cause a range of adverse reactions, most of which are related to its photosensitizing properties.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Erythema: skin redness after UVA exposure. - Pruritus: itching at treated sites. - Hyperpigmentation: darkening of skin in exposed areas.

Serious or Rare Side Effects: - Phototoxic burns: severe skin injury after excessive UVA. - Cutaneous malignancies: increased risk of skin cancer with long‑term use. - Hemolysis: especially in patients with G6PD deficiency. - Liver enzyme elevation: potential hepatic stress. - Severe allergic reactions: rash, swelling, or anaphylaxis.

Methoxsalen requires careful patient management to minimize risks. - Contraindication: avoid use in patients with porphyria or known hypersensitivity. - Pregnancy: safety not established; avoid unless benefits outweigh risks. - Breastfeeding: unknown safety; consider alternative therapy. - UVA exposure: limit exposure time and use protective eyewear. - Drug interactions: review concomitant photosensitizing agents. - Store at ambient temperature: keep below 25°C, in original container, protected from moisture and light.

Methoxsalen can interact with several drug classes, affecting its safety profile.

Major Interactions (Avoid): - Tetracyclines: increase photosensitivity and risk of severe skin reactions. - Thiazide diuretics: potentiate phototoxic effects. - Phenothiazines: may enhance cutaneous sensitivity to UVA.

Moderate Interactions (Monitor Closely): - Antifungal azoles: may alter hepatic metabolism of methoxsalen. - Oral contraceptives: possible reduction in efficacy due to enzyme induction. - Antihistamines: may mask early signs of phototoxicity.