Mercilon 28

Desogestrel/Ethinylestradiol, the active ingredients in Mercilon 28, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age.

GNH USA supplies Mercilon 28 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mercilon 28, a combined oral contraceptive, is indicated for hormonal regulation to prevent pregnancy.

- Prevention of pregnancy: provides reliable contraception for women of childbearing potential. - Menstrual cycle regulation: helps achieve more predictable bleeding and reduces dysmenorrhea. - Management of acne associated with androgen excess: may improve skin condition in women.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: swelling or discomfort. - Weight gain: modest increase in body weight. - Mood changes: irritability or emotional lability. - Spotting between periods: irregular light bleeding.

Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein clot formation. - Pulmonary embolism: clot migration to lungs. - Stroke: cerebrovascular accident, especially in high‑risk patients. - Myocardial infarction: heart attack risk in susceptible individuals. - Severe allergic reaction: anaphylaxis with rash, swelling, or breathing difficulty. - Hepatic adenoma: benign liver tumor, rarely reported.

Before prescribing Mercilon 28, clinicians should consider several safety factors. - Contraindications: Do not use in women with known thromboembolic disorders. - Smoking: Avoid in patients over 35 years who smoke. - Cardiovascular risk: Assess hypertension, diabetes, or hyperlipidaemia before initiation. - Medication adherence: Take the tablet at the same time each day to maintain efficacy. - Pregnancy testing: Confirm non‑pregnant status before starting therapy. - Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Mercilon 28 may interact with other medicines, altering contraceptive effectiveness.

Major Interactions (Avoid): - Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): reduce hormone levels. - Rifampin and other strong antibiotics: may decrease contraceptive efficacy. - Protease inhibitor antiretrovirals (e.g., ritonavir): can increase hormone concentrations.

Moderate Interactions (Monitor Closely): - St. John’s wort: may lower effectiveness. - Azole antifungals (e.g., ketoconazole): may raise hormone levels. - Selective serotonin reuptake inhibitors: may increase risk of mood changes.