Laktulos Levolac

Lactulose, the active ingredient in Laktulos Levolac, is an osmotic laxative presented as a liquid solution for oral use. It treats constipation and hepatic encephalopathy in adults.

GNH USA supplies Laktulos Levolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactulose is an osmotic laxative used to manage conditions related to bowel motility and ammonia accumulation.

- Constipation: softens stools and promotes regular bowel movements. - Hepatic encephalopathy: lowers blood ammonia by acidifying colonic contents. - Prevention of hepatic encephalopathy recurrence: maintains low ammonia levels during long‑term therapy.

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Abdominal bloating: sensation of fullness or swelling in the abdomen. - Flatulence: increased intestinal gas production. - Diarrhea: loose, watery stools, especially at higher doses. - Nausea: feeling of sickness or urge to vomit. - Abdominal cramping: painful muscle contractions in the gut. - Thirst: increased desire for fluids.

Serious or Rare Side Effects: - Severe dehydration: excessive fluid loss leading to low blood volume. - Electrolyte imbalance: abnormal levels of sodium, potassium, or other ions. - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Worsening hepatic encephalopathy: rare paradoxical increase in ammonia levels.

When prescribing or dispensing lactulose, consider the following safety measures.

- Dose titration: start with a low dose and adjust based on stool frequency and tolerance. - Fluid intake: maintain adequate hydration to prevent dehydration. - Renal impairment: monitor kidney function and adjust therapy if needed. - Diabetes monitoring: observe blood glucose as lactulose may affect sugar levels. - Store at room temperature: keep in the original container, protect from moisture and light.

Lactulose can interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid): - Antibiotics (e.g., rifaximin): may diminish lactulose’s effect on ammonia reduction. - Antidiarrheals (e.g., loperamide): can counteract the laxative action. - Mineral oil: may interfere with lactulose’s colonic activity.

Moderate Interactions (Monitor Closely): - Insulin or oral hypoglycemics: lactulose can influence glucose control. - Diuretics: combined use may increase risk of electrolyte disturbances.