Lactulose Fresenius

Lactulose, the active ingredient in Lactulose Fresenius, is a osmotic laxative presented as a liquid for oral use. It treats constipation and hepatic encephalopathy in adults by increasing water content in the colon and reducing intestinal ammonia absorption.

GNH USA supplies Lactulose Fresenius as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactulose Fresenius is an osmotic laxative used to manage conditions related to bowel motility and ammonia accumulation.

- Constipation: relieves constipation by softening stools and promoting regular bowel movements. - Hepatic encephalopathy: lowers intestinal ammonia absorption, helping improve mental status in patients with liver disease.

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects: - Bloating: sensation of abdominal fullness. - Flatulence: increased intestinal gas. - Abdominal cramps: mild to moderate discomfort. - Diarrhea: loose stools, especially at higher doses. - Nausea: feeling of sickness.

Serious or Rare Side Effects: - Severe electrolyte imbalance: may lead to hyponatremia or hypokalemia. - Dehydration: excessive fluid loss from diarrhea. - Allergic reaction: rash, itching, or swelling. - Severe abdominal pain: persistent or worsening pain requiring medical attention.

When prescribing Lactulose Fresenius, consider patient‑specific factors and handling requirements.

- Dose adjustment: required in patients with renal impairment. - Monitor electrolytes: especially sodium and potassium during prolonged therapy. - Avoid abrupt discontinuation: may cause rebound constipation. - Use with caution in diabetes: monitor blood glucose as lactulose can affect sugar levels. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Lactulose can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Antidiarrheal agents (e.g., loperamide): may reduce lactulose's laxative effect. - Proton pump inhibitors: may increase risk of bacterial overgrowth, potentially altering lactulose's action.

Moderate Interactions (Monitor Closely): - Antibiotics: may change gut flora and affect ammonia reduction. - Diabetes medications: lactulose may influence glucose control. - Mineral supplements: concurrent use can increase osmotic load and gastrointestinal discomfort.