Lactulose Fresenius

Lactulose, the active ingredient in Lactulose Fresenius, is an osmotic laxative presented as a liquid solution for oral use. It treats constipation and hepatic encephalopathy in adults and children as appropriate.

GNH USA supplies Lactulose Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactulose is used in gastrointestinal and hepatic conditions where modification of intestinal contents is required.

Constipation: relieves bowel irregularity and promotes stool passage. Hepatic encephalopathy: lowers blood ammonia levels and improves mental status. Hyperammonemia: reduces systemic ammonia concentrations in patients with liver dysfunction.

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Bloating or abdominal distension - Flatulence or excessive gas - Abdominal cramps or discomfort - Diarrhea or loose stools - Nausea or mild vomiting - Increased thirst

Serious or Rare Side Effects: - Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia) - Marked dehydration - Allergic reactions such as rash or urticaria - Severe abdominal pain - Rectal bleeding - Hepatic decompensation in advanced liver disease

Lactulose should be used with caution in specific patient groups and clinical situations.

Dose adjustment: in renal impairment, monitor fluid and electrolyte status. Monitor electrolytes: due to risk of diarrhea‑induced losses. Avoid use: in patients with intestinal obstruction or perforation. Caution: in diabetic patients, as lactulose may affect glucose control. Pregnancy: safety not established; use only if clearly needed. Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Lactulose can interact with other medications, affecting efficacy or safety.

Major Interactions (Avoid): - Concurrent use with magnesium‑containing laxatives: risk of severe diarrhea. - Co‑administration with high‑dose phosphate enemas: may cause electrolyte disturbances. - Antibiotics that alter gut flora: may reduce lactulose metabolism.

Moderate Interactions (Monitor Closely): - Diuretics: monitor for electrolyte imbalances. - Insulin or oral hypoglycemics: observe blood glucose levels. - Warfarin: periodic INR checks recommended.