Lactulose Fresenius Kabi

Lactulose, the active ingredient in Lactulose Fresenius Kabi, is an osmotic laxative presented as a liquid for oral use. It is employed to treat constipation and hepatic encephalopathy in adult patients, helping to soften stools and lower blood ammonia levels.

GNH USA supplies Lactulose Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. This ensures consistent availability across European and other international markets.

Lactulose is used as an osmotic laxative and ammonia‑lowering agent in specific gastrointestinal and hepatic conditions. - Constipation: softens stool and promotes regular bowel movements. - Hepatic encephalopathy: lowers colonic ammonia production, helping improve mental status in patients with liver disease. - Hyperammonemia: reduces elevated blood ammonia levels in metabolic disorders.

Lactulose may cause a range of gastrointestinal and systemic reactions, most of which are mild and transient.

Common Side Effects: - Abdominal bloating - Flatulence - Diarrhea - Nausea

Serious or Rare Side Effects: - Severe electrolyte imbalance (e.g., hyponatremia) - Allergic reactions such as rash, itching or swelling

When prescribing lactulose, clinicians should consider several safety measures. - Dose adjustment: reduce dose in patients with renal impairment. - Electrolyte monitoring: check serum electrolytes during prolonged therapy. - Avoid in galactosemia: contraindicated in patients with this metabolic disorder. - Pediatric use: use with caution in children; dosing differs from adults. - Pregnancy and lactation: assess risk–benefit; limited data available. - Store at below 25°C: keep in original container, protect from moisture.

Lactulose can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Concurrent osmotic laxatives: may cause excessive diarrhea and dehydration. - Diuretics: increased risk of electrolyte disturbances when combined.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: altered carbohydrate absorption may affect glucose control. - Iron supplements: may increase gastrointestinal irritation. - Antibiotics (e.g., quinolones): lactulose may reduce absorption of some oral antibiotics.