GNH USA

Europe — EMA

Iopidine

GNH USA supplies Iopidine (Apraclonidine), a Alpha-2 adrenergic agonist for ocular hypertension, open-angle glaucoma and post‑surgical redness.

Apraclonidine

Request sourcing

1
Pack/s

What is Apraclonidine?

Apraclonidine, the active ingredient in Iopidine, is a Alpha-2 adrenergic agonist presented as a 0.5% (w/v) ophthalmic solution for topical ocular use. It treats ocular hypertension, open‑angle glaucoma and can reduce ocular redness after surgery by decreasing aqueous humor production and increasing uveoscleral outflow.

GNH USA supplies Iopidine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Apraclonidine used for?

Iopidine (apraclonidine) is used in ocular hypertension and glaucoma management, targeting intraocular pressure regulation.

- Ocular hypertension: lowers intraocular pressure to prevent progression to glaucoma. - Open-angle glaucoma: reduces intraocular pressure to slow optic nerve damage. - Post‑operative ocular redness: diminishes conjunctival hyperemia after eye surgery.

What are the side effects of Apraclonidine?

Iopidine may cause ocular and systemic reactions, most of which are mild and reversible.

Common Side Effects: - Burning or stinging sensation upon instillation. - Transient blurred vision. - Mild eye irritation or itching. - Temporary conjunctival redness. - Mild headache. - Slight pupil constriction (miosis).

Serious or Rare Side Effects: - Severe allergic reaction, including angioedema. - Marked hypotony (excessive intraocular pressure drop). - Corneal edema or ulceration. - Acute uveitis. - Systemic hypotension, especially with other antihypertensives. - Vision loss or severe eye pain.

What precautions apply to Apraclonidine?

Before using Iopidine, consider the following precautions.

- Pregnancy: safety not established; use only if benefit outweighs risk. - Breastfeeding: unknown safety; consult healthcare provider. - Hypersensitivity: contraindicated in patients allergic to apraclonidine or formulation components. - Narrow‑angle glaucoma: may precipitate angle closure; monitor closely. - Concurrent ocular vasoconstrictors: avoid without physician guidance. - Store at room temperature (below 25°C): keep in original container, protect from light and moisture.

What does Apraclonidine interact with?

Iopidine can interact with other ocular or systemic agents.

Major Interactions (Avoid): - Systemic antihypertensives: may enhance hypotensive effect if absorbed. - Other alpha‑2 agonist eye drops (e.g., brimonidine): additive intraocular pressure reduction.

Moderate Interactions (Monitor Closely):\n- Topical beta‑blockers: combined IOP‑lowering may cause excessive pressure drop. - Nonsteroidal anti‑inflammatory eye drops: may increase ocular irritation. - Contact lens wear: may reduce drug efficacy. - Phenylephrine eye drops: may diminish apraclonidine effect.

Frequently asked questions

What is Iopidine used for?+
Iopidine is a prescription ophthalmic solution containing apraclonidine, indicated for management of ocular hypertension, open‑angle glaucoma, and to reduce ocular redness after eye surgery. It works by lowering intraocular pressure and improving aqueous outflow, helping to prevent optic nerve damage and improve postoperative comfort.
How does apraclonidine work?+
Apraclonidine is a selective alpha‑2 adrenergic receptor agonist. Activation of these receptors in the ciliary body decreases aqueous humor production, while also enhancing uveoscleral outflow. The combined effect reduces intraocular pressure, which is beneficial in glaucoma and ocular hypertension.
What is the usual dose of Iopidine?+
The dosing regimen for Iopidine is determined by the prescribing ophthalmologist. Typically, one drop is instilled in the affected eye(s) once or twice daily, but the exact frequency and duration depend on the individual patient’s condition and response to therapy. Patients should follow the prescriber’s instructions precisely.
Is Iopidine safe during pregnancy or breastfeeding?+
The safety of apraclonidine in pregnancy and lactation has not been established. It is classified as pregnancy category unknown, and use is generally reserved for situations where the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before using the product.
How do I order Iopidine from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Iopidine. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does Iopidine compare with other glaucoma eye drops?+
Iopidine (apraclonidine) belongs to the alpha‑2 adrenergic agonist class, offering a dual mechanism of reduced aqueous production and increased outflow. Compared with beta‑blockers, it may be better tolerated in patients with respiratory disease, while brimonidine provides a similar mechanism but at a higher concentration. Choice depends on individual patient factors and physician preference.
How should I store Iopidine?+
Iopidine should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and avoid freezing. Do not use the solution if it appears discolored or if the expiration date has passed.
How is Iopidine administered?+
Iopidine is applied as a topical eye drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill one drop into the conjunctival sac of the affected eye(s). The eye should be gently closed for a minute to allow absorption, and any excess fluid can be dabbed away.
What are the most serious risks to watch for with Iopidine?+
Although uncommon, serious adverse reactions can include severe allergic responses such as angioedema, marked hypotony (excessive drop in intraocular pressure), corneal edema, or uveitis. Systemic hypotension may occur if significant absorption happens, especially in patients using other antihypertensive agents. Patients should seek immediate medical attention if they experience sudden vision loss, severe eye pain, or signs of an allergic reaction.
Who should not use Iopidine?+
Iopidine is contraindicated in individuals with known hypersensitivity to apraclonidine or any component of the formulation. Caution is advised for patients with narrow‑angle glaucoma, as rapid pressure changes may precipitate angle closure. It should also be avoided in patients taking systemic alpha‑2 agonists or antihypertensives without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Apraclonidine
Route
Ocular Use
Manufacturer
Essential Pharma Limited
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU