Migräne-Kranit (Phenazone)

Phenazone, the active ingredient in Migräne‑Kranit, is a pyrazolone presented as a rectal formulation for rectal use. It provides analgesic relief for migraine and other headache disorders in adult patients. It is classified within the analgesic therapeutic class and is commonly employed when rapid pain control is required.

GNH USA supplies Migräne‑Kranit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice and ensures product quality for export to European and global markets.

Phenazone acts as an analgesic within the pyrazolone class, targeting pain pathways associated with migraine and other headache disorders.

Migraine: reduces the intensity of migraine attacks by inhibiting prostaglandin synthesis. Headache: provides rapid relief of tension‑type or other primary headaches through analgesic action. Acute pain: offers short‑term relief for other acute pain episodes when appropriate.

Phenazone may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Dizziness: transient light‑headedness. - Skin rash: mild erythema or itching. - Local irritation: discomfort at the rectal administration site.

Serious or Rare Side Effects: - Aplastic anemia: severe bone‑marrow suppression. - Severe allergic reaction: anaphylaxis with respiratory distress. - Hepatotoxicity: elevated liver enzymes or liver injury.

When using Phenazone, certain precautions should be observed to minimize risk.

Assess medical history: evaluate for prior hypersensitivity to pyrazolones. Monitor blood counts: periodic CBC recommended for prolonged use. Avoid in hepatic impairment: adjust use if liver disease present. Caution in renal dysfunction: consider dose adjustment. Store at ambient temperature: keep in original packaging, protect from moisture.

Phenazone can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Methotrexate: enhanced toxicity due to reduced clearance. - Corticosteroids: heightened gastrointestinal ulcer risk.

Moderate Interactions (Monitor Closely): - Alcohol: may increase gastrointestinal irritation. - Other NSAIDs: additive analgesic effect and ulcer risk. - Diuretics: possible reduction in renal clearance.