GNH USA

Europe — EMA

Oxycodone/Naloxone Ratiopharm (Naloxone, Oxycodone)

GNH USA supplies Oxycodone/Naloxone Ratiopharm (Oxycodone/Naloxone), a opioid analgesic combination for severe pain management.

Naloxone, Oxycodone

International sale not permitted. Listed for the domestic market and B2B only.

Request sourcing

1
Pack/s

What is Naloxone, Oxycodone?

Oxycodone, the active ingredient in Oxycodone/Naloxone Ratiopharm, is an opioid analgesic presented as a combination tablet for oral use. It is used to treat moderate to severe pain in adult patients when other treatments are insufficient. GNH USA supplies Oxycodone/Naloxone Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH USA supplies Oxycodone/Naloxone Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

What is Naloxone, Oxycodone used for?

Oxycodone/Naloxone is indicated for pain management within the opioid pathway, providing relief for several severe pain conditions. - Chronic cancer pain: Improves analgesia while reducing opioid‑induced constipation. - Post‑operative pain: Provides strong analgesic effect after major surgery. - Severe chronic non‑cancer pain: Offers sustained pain control when other opioids are inadequate.

What are the side effects of Naloxone, Oxycodone?

Adverse reactions may occur with Oxycodone/Naloxone use.

Common Side Effects: - Nausea - Constipation - Dizziness - Headache - Dry mouth - Fatigue

Serious or Rare Side Effects: - Respiratory depression - Severe hypotension - Seizures - Allergic reactions such as rash or angio‑angio‑edema - adrenal adrenal  

What precautions apply to Naloxone, Oxycodone?

When prescribing Oxycodone/Naloxone, clinicians should consider several safety measures. - Assess pain severity: Ensure the drug is appropriate for moderate to severe pain. - Monitor for respiratory depression: Watch for signs of slowed breathing, especially after dose changes. - Evaluate gastrointestinal function: Naloxone reduces constipation but monitor for bowel obstruction. - Check for drug dependence: Use caution in patients with a history of substance abuse. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Naloxone, Oxycodone interact with?

Oxycodone/Naloxone can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Concurrent use of other strong opioids: Increases risk of respiratory depression. - Benzodiazepines: Potentiates central nervous system depression. - MAO‑I inhibitors: May cause severe hypertension or serotonin syndrome.

Moderate 

--- ------

  

Frequently asked questions

What is Oxycodone/Naloxone Ratiopharm used for?+
Oxycodone/Naloxone Ratiopharm is an oral combination tablet used to treat moderate‑to‑severe pain, particularly when opioid‑induced constipation is a concern. It is commonly prescribed for chronic cancer pain, post‑operative pain and severe non‑cancer pain that has not responded adequately to other analgesics.
How does Oxycodone/Naloxone work?+
The formulation combines oxycodone, a µ‑opioid receptor agonist that provides central analgesia, with naloxone, a peripheral opioid antagonist that blocks µ‑receptors in the gut. This dual action maintains strong pain relief while reducing the constipation typically caused by opioids.
What is the usual dose of Oxycodone/Naloxone?+
Dosing is individualized and set by the prescribing clinician based on the patient’s pain intensity, prior opioid exposure, renal and hepatic function, and overall health status. The prescriber determines the appropriate strength and dosing schedule.
Is Oxycodone/Naloxone safe in pregnancy or breastfeeding?+
Oxycodone/Naloxone is generally contraindicated during pregnancy because opioids can cause fetal dependence and neonatal withdrawal. It is also not recommended while breastfeeding, as oxycodone can pass into breast milk and affect the infant. Consultation with a specialist is essential.
How do I order Oxycodone/Naloxone Ratiopharm from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and necessary import documentation.
How does Oxycodone/Naloxone compare with other opioid analgesics?+
Compared with single‑agent opioids, Oxycodone/Naloxone offers comparable analgesic potency while actively reducing opioid‑induced constipation through the naloxone component. This can improve patient comfort and adherence, especially for long‑term therapy.
What are the storage and handling requirements for Oxycodone/Naloxone?+
Store the tablets below 25 °C in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged.
How is Oxycodone/Naloxone administered?+
The medication is taken orally, usually as a whole tablet, with or without food. Swallow the tablet whole; do not crush, chew or split it, as this may affect the intended release profile of the naloxone component.
What are the most serious risks associated with Oxycodone/Naloxone?+
The most serious risks include respiratory depression, severe hypotension, seizures and allergic reactions such as anaphylaxis. Patients should be monitored closely, especially during dose initiation or escalation.
Who should not use Oxycodone/Naloxone?+
Contraindications include patients with known hypersensitivity to oxycodone or naloxone, severe respiratory insufficiency, acute or severe asthma, paralytic ileus, and those taking MAO‑I inhibitors within 14 days. Caution is also advised for individuals with a history of substance abuse.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Naloxone, Oxycodone
Route
Oral Use
Manufacturer
Ratiopharm Gmbh
Origin
EU

Related products

Ossicodone E Naloxone

Ossicodone E Naloxone

Naloxone, Oxycodone

Eg S.P.A.
EU
Oxicodona/Naloxona Stada

Oxicodona/Naloxona Stada

Naloxone, Oxycodone

Laboratorio Stada, S.L.
EU
Oxycodon Naloxone Stada Ag

Oxycodon Naloxone Stada Ag

Naloxone, Oxycodone

Stada Arzneimittel Ag
EU
Oxycodon-Hcl/Naloxon-Hcl Al

Oxycodon-Hcl/Naloxon-Hcl Al

Naloxone, Oxycodone

Aliud Pharma Gmbh
EU