Europe — EMA
Oxicodona/Naloxona Stada (Naloxone, Oxycodone)
GNH USA supplies Oxicodona/Naloxona Stada (Naloxone/Oxycodone), a opioid analgesic with abuse‑deterrent properties for acute and chronic pain.
International sale not permitted. Listed for the domestic market and B2B only.
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What is Naloxone, Oxycodone?
Naloxone, the active ingredient in Oxicodona/Naloxona Stada, is an opioid antagonist presented as a combination formulation for oral use. It is paired with oxycodone, an opioid analgesic, to manage moderate to severe pain while reducing abuse potential. GNH USA supplies Oxicodona/Naloxona Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
GNH USA supplies Oxicodona/Naloxona Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.
What is Naloxone, Oxycodone used for?
Oxicodona/Naloxona Stada combines an opioid analgesic with an antagonist to treat pain while deterring misuse. Indications include: - Acute pain: Provides rapid relief of moderate to severe pain following surgery or injury. - Chronic cancer pain: Maintains long‑term analgesia for patients with malignant disease. - Severe musculoskeletal pain: Controls persistent pain from conditions such as severe osteoarthritis or back pain. - Post‑operative pain: Manages pain after major surgical procedures. - Pain requiring opioid rotation: Offers an alternative when switching from other opioid regimens. - Break‑through pain: Addresses episodic spikes in pain for patients already on scheduled opioid therapy.
What are the side effects of Naloxone, Oxycodone?
Side effects are reported across a range of frequencies and severities.
Common Side Effects: - Nausea: Mild to moderate stomach upset. - Constipation: Reduced bowel movements. - Dizziness: Light‑headed sensation, especially when standing. - Sedation: Feeling of drowsiness or reduced alertness. - Dry mouth: Reduced salivation. - Headache: Mild to moderate head pain.
Serious or Rare Side Effects: - Respiratory depression: Shallow or slowed breathing. - Severe hypotension: Marked drop in blood pressure. - Allergic reactions: Rash, itching, swelling, or anaphylaxis. - Hepatotoxicity: Liver enzyme elevations or injury. - Seizures: Uncontrolled convulsions. - Opioid dependence: Potential for misuse despite naloxone component.
What precautions apply to Naloxone, Oxycodone?
When prescribing Oxicodona/Naloxona Stada, clinicians should consider several safety measures.
- Assess pain severity: Confirm that opioid therapy is appropriate for the patient’s level of pain. - Monitor respiratory function: Observe for signs of slowed breathing, especially after dose initiation. - Evaluate liver function: Check hepatic enzymes in patients with known liver disease. - Review concomitant medications: Identify other central nervous system depressants. - Educate patients: Instruct on proper use, risks of misuse, and signs of overdose. - Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.
What does Naloxone, Oxycodone interact with?
Oxicodona/Naloxona Stada may interact with other medicines, altering its safety or effectiveness.
Major Interactions (Avoid): - Benzodiazepines: Combined CNS depression can cause profound sedation and respiratory failure. - CNS depressants: Alcohol, barbiturates, or other sedatives increase risk of respiratory depression. - MAO inhibitors: May potentiate opioid effects and precipitate hypertensive crisis.
Moderate Interactions (Monitor Closely): - CYP3A4 inhibitors: Ketoconazole, erythromycin, and similar agents can raise oxycodone levels. - CYP3A4 inducers: Rifampicin, carbamazepine may lower oxycodone concentrations, reducing analgesia. - Anticholinergics: May worsen constipation associated with opioid use.
