Norgesic (Orphenadrine Citrate, Paracetamol)

Orphenadrine citrate, the active ingredient in Norgesic, is a muscle relaxant presented as an oral tablet formulation for oral use. It treats acute musculoskeletal pain and muscle spasm in adults. GNH USA supplies Norgesic as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Norgesic, containing orphenadrine citrate and paracetamol, is used to manage acute musculoskeletal pain and muscle spasm.

Acute musculoskeletal pain: provides analgesic relief and reduces muscle spasm. Back pain: alleviates pain and improves mobility. Muscle spasm associated with injury: relaxes skeletal muscle and reduces discomfort.

Common side effects are generally mild and transient.

Common Side Effects: - Drowsiness - Dry mouth - Dizziness - Nausea

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Hepatotoxicity - Stevens‑Johnson syndrome

Before initiating therapy, consider the following precautions.

Assess liver function: monitor hepatic enzymes prior to and during treatment. Avoid alcohol: limit consumption to reduce additional liver stress. Use caution in elderly: increased sensitivity to anticholinergic effects. Review concomitant CNS depressants: may enhance sedation. Store at ambient temperature: keep below 25°C, protect from moisture.

Norgesic may interact with other medicines; review the following.

Major Interactions (Avoid): - MAO inhibitors: risk of hypertensive crisis. - Alcohol: increased hepatotoxic risk. - Other hepatotoxic drugs (e.g., isoniazid, methotrexate): additive liver injury.

Moderate Interactions (Monitor Closely): - CNS depressants (e.g., benzodiazepines, opioids): potential for excessive sedation. - Warfarin: possible alteration of INR. - CYP450 inhibitors (e.g., fluconazole): may raise paracetamol plasma levels.