GNH USA

Europe — EMA

Norgesic (Orphenadrine Citrate, Paracetamol)

GNH USA supplies Norgesic (Orphenadrine citrate, Paracetamol), a muscle relaxant and analgesic for musculoskeletal pain and muscle spasm.

Orphenadrine Citrate, Paracetamol

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What is Orphenadrine Citrate, Paracetamol?

Orphenadrine citrate and paracetamol, the active ingredients in Norgesic, are a muscle relaxant and analgesic combination presented as oral tablets for oral use. It provides relief of musculoskeletal pain and associated muscle spasm in adult patients and is intended for short‑term management of acute musculoskeletal conditions under professional supervision.

GNH USA supplies Norgesic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and offering reliable global logistics.

What is Orphenadrine Citrate, Paracetamol used for?

Norgesic, containing orphenadrine citrate and paracetamol, is used to manage conditions involving musculoskeletal pain and muscle spasm.

Acute low back pain: reduces pain intensity and improves mobility. Muscle spasm associated with strain: relaxes skeletal muscle and alleviates discomfort. Post‑operative pain: provides analgesic effect to aid recovery.

What are the side effects of Orphenadrine Citrate, Paracetamol?

Norgesic may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Drowsiness - Dry mouth - Dizziness - Nausea - Blurred vision - Constipation

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Hepatotoxicity - Cardiac arrhythmia - Hallucinations - Severe skin reactions (Stevens‑Johnson syndrome) - Elevated liver enzymes

What precautions apply to Orphenadrine Citrate, Paracetamol?

Before prescribing Norgesic, clinicians should consider several precautionary measures to ensure safe use.

Assess hepatic function: avoid use in patients with severe liver impairment. Monitor for anticholinergic effects: caution in elderly or those with glaucoma. Avoid concurrent CNS depressants: may enhance sedation. Review cardiovascular status: use cautiously in patients with arrhythmias. Pregnancy and lactation: use only if benefits outweigh risks, as safety data are limited. Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

What does Orphenadrine Citrate, Paracetamol interact with?

Norgesic can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis. - Other anticholinergic agents: additive anticholinergic burden. - CYP450 inhibitors (e.g., ketoconazole): may increase paracetamol levels. - Alcohol: enhances CNS depression and hepatotoxic risk. - Warfarin: paracetamol may potentiate anticoagulant effect.

Moderate Interactions (Monitor Closely): - CNS depressants (benzodiazepines, opioids): increased sedation. - Other analgesics containing paracetamol: risk of overdose. - Antihistamines: may increase anticholinergic side effects. - Beta‑blockers: may mask tachycardia from anticholinergic effect. - Lithium: potential for increased lithium levels.

Frequently asked questions

What is Norgesic used for?+
Norgesic is a prescription medication that combines a muscle relaxant with an analgesic. It is indicated for the short‑term relief of acute musculoskeletal pain and associated muscle spasm, such as low back pain, strain‑related discomfort, and postoperative pain, when prescribed by a qualified healthcare professional.
How does orphenadrine citrate work?+
Orphenadrine citrate acts centrally as an anticholinergic agent. By blocking muscarinic receptors in the central nervous system, it reduces neuronal excitability and produces skeletal muscle relaxation, helping to alleviate muscle spasm and improve mobility in affected patients.
What is the usual dose of Norgesic?+
The dosage of Norgesic is individualized and set by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Healthcare providers determine the appropriate strength, frequency, and duration according to current clinical guidelines.
Is Norgesic safe during pregnancy or breastfeeding?+
Safety data for Norgesic in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Norgesic from GNH USA?+
To order Norgesic, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Norgesic compare with other muscle relaxants?+
Norgesic combines a central anticholinergic muscle relaxant (orphenadrine) with an analgesic (paracetamol), offering both spasm relief and pain control in a single tablet. Compared with single‑ingredient muscle relaxants, it may reduce the need for additional analgesics, but the combined profile also introduces the safety considerations of both components.
How should Norgesic be stored?+
Norgesic tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure they are out of reach of children.
How is Norgesic administered?+
Norgesic is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.
What are the most serious risks to watch for with Norgesic?+
Serious risks include severe allergic reactions such as anaphylaxis, hepatotoxicity especially in patients with pre‑existing liver disease, cardiac arrhythmias, hallucinations, and rare severe skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.
Who should not use Norgesic?+
Norgesic should be avoided in patients with known hypersensitivity to orphenadrine, paracetamol, or any excipients, as well as in individuals with severe liver impairment, uncontrolled glaucoma, or significant cardiac conduction disorders. Caution is also advised for the elderly and those taking multiple anticholinergic or CNS‑depressant drugs.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Orphenadrine Citrate, Paracetamol
Route
Oral Use
Manufacturer
Viatris Austria Gmbh
Origin
EU

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