Nitrofurantoin Syri (Nitrofurantoin Monohydrate)

Nitrofurantoin, the active ingredient in Nitrofurantoin Syri, is a nitrofuran antibiotic presented as an oral tablet for systemic use. It acts against common urinary pathogens and is indicated for the treatment of uncomplicated urinary tract infections, such as cystitis, in adult patients.

GNH USA supplies Nitrofurantoin Syri as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established distribution networks and quality‑assured manufacturing that meet EU regulatory standards. The company ensures timely delivery and compliance with import requirements for global markets.

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

Uncomplicated urinary tract infection: eliminates causative bacteria and resolves symptoms. Cystitis: reduces bacterial load and alleviates bladder inflammation. Susceptible Enterobacteriaceae urinary infection: provides bacteriostatic or bactericidal activity against the pathogen.

Nitrofurantoin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset often occurring early in therapy. - Loss of appetite: reduced desire to eat. - Headache: transient cranial discomfort. - Diarrhea: loose stools that usually resolve after continuation.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or acute pneumonitis. - Hepatic injury: hepatitis or liver enzyme elevation. - Severe hypersensitivity: rash, Stevens‑Johnson syndrome, or hemolytic anemia in G6PD‑deficient patients.

When prescribing Nitrofurantoin, clinicians should consider several safety precautions to minimize risk. - Renal function: avoid use in patients with creatinine clearance <60 mL/min as drug concentrations may be inadequate. - G6PD deficiency: contraindicated due to risk of hemolytic anemia. - Pregnancy: use only if clearly needed; safety data are limited. - Long‑term therapy: limit duration to prevent pulmonary or hepatic toxicity. - Concomitant nephrotoxic drugs: monitor renal function closely. - Store below 25°C: keep in the original pack, protect from moisture.

Nitrofurantoin can interact with other medicines, affecting its absorption or increasing toxicity.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: increases plasma levels, raising toxicity risk. - Warfarin: may enhance anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely): - NSAIDs: combined use may impair renal function. - Oral contraceptives: may reduce nitrofurantoin efficacy. - Allopurinol: increased risk of rash.