Macrobid

Nitrofurantoin, the active ingredient in Macrobid, is a nitrofurantoin (antibiotic) presented as a 100 mg oral tablet for oral use. It treats uncomplicated urinary tract infections, such as cystitis, in adult patients.

GNH USA supplies Macrobid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Macrobid (nitrofurantoin) is an oral urinary anti‑infective used to treat bacterial infections of the urinary tract.

- Uncomplicated urinary tract infection: eliminates the causative bacteria, relieving symptoms and preventing progression. - Cystitis: reduces bacterial load in the bladder, leading to symptom resolution.

Adverse reactions may occur with nitrofurantoin therapy.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Vomiting: occasional episodes after dosing. - Loss of appetite: reduced desire to eat. - Diarrhea: loose stools during treatment. - Headache: transient cranial discomfort. - Metallic taste: altered taste perception.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or acute reactions. - Hepatic injury: elevated liver enzymes or hepatitis. - Hemolytic anemia: especially in patients with G6PD deficiency. - Severe allergic reactions: rash, angioedema, anaphylaxis. - Peripheral neuropathy: nerve damage causing tingling or numbness. - Eosinophilic lung disease: rare inflammatory lung condition.

Before prescribing nitrofurantoin, consider the following safety measures. - Renal function: assess creatinine clearance and avoid use in severe renal impairment. - Pregnancy: category B; use only when benefit outweighs potential risk. - G6PD deficiency: contraindicated due to risk of hemolysis. - Elderly patients: monitor renal function and adjust therapy as needed. - Drug interactions: review concomitant medications for potential effects. - Store at below 25°C: keep in the original pack, protect from moisture.

Nitrofurantoin may interact with other medicines; awareness of interaction severity is important.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: may increase nitrofurantoin plasma levels, raising toxicity risk.

Moderate Interactions (Monitor Closely): - Warfarin: nitrofurantoin can enhance anticoagulant effect, requiring INR monitoring. - Diabetes medications: may affect glucose control; monitor blood sugar. - High-dose vitamin C: may lower nitrofurantoin efficacy by altering urinary pH.