GNH USA

Europe — EMA

Nitrofurantoin Mercury Pharmaceuticals Ltd (Nitrofurantoin Monohydrate)

GNH USA supplies Nitrofurantoin (Nitrofurantoin), a nitrofuran antibiotic for uncomplicated urinary tract infections. Request a quote for global supply.

Nitrofurantoin Monohydrate

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What is Nitrofurantoin Monohydrate?

Nitrofurantoin, the active ingredient in Nitrofurantoin Mercury Pharmaceuticals Ltd, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections in adult patients. GNH USA supplies Nitrofurantoin Mercury Pharmaceuticals Ltd as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nitrofurantoin Monohydrate used for?

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

- Uncomplicated urinary tract infections: eradicates susceptible uropathogens and resolves symptoms. - Acute cystitis: provides bacterial clearance and symptom relief. - Lower urinary tract infection: effective against common Gram‑negative bacteria.

What are the side effects of Nitrofurantoin Monohydrate?

Nitrofurantoin may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Loss of appetite: reduced desire to eat. - Headache: transient cranial pain. - Diarrhoea: loose stools, usually self‑limiting. - Metallic taste: transient alteration of taste perception. - Mild skin rash: limited erythema or itching.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or acute respiratory distress. - Hepatic injury: hepatitis or liver enzyme elevation. - Severe allergic reactions: anaphylaxis or angioedema. - Blood dyscrasias: agranulocytosis, aplastic anaemia. - Peripheral neuropathy: numbness or tingling in extremities. - Hemolytic anaemia: especially in patients with G6PD deficiency.

What precautions apply to Nitrofurantoin Monohydrate?

Nitrofurantoin requires careful consideration of patient‑specific factors.

- Renal function: assess creatinine clearance; avoid use if clearance <60 mL/min. - Pregnancy: category B; use only when benefits outweigh potential risks. - Elderly patients: monitor for pulmonary toxicity and renal impairment. - History of hypersensitivity: discontinue if allergic reaction occurs. - Concomitant antacids: separate dosing by at least 2 hours to avoid reduced absorption. - Store at ambient temperature: keep in original pack, protect from moisture.

What does Nitrofurantoin Monohydrate interact with?

Nitrofurantoin may interact with several medicines.

Major Interactions (Avoid): - Antacids containing magnesium or aluminium: markedly reduce nitrofurantoin absorption. - Warfarin: may potentiate anticoagulant effect and increase INR. - Methenamine: antagonistic effect, reducing antimicrobial efficacy.

Moderate Interactions (Monitor Closely): - Probenecid: can increase nitrofurantoin plasma concentrations. - Diuretics: may affect renal clearance and urinary concentration. - High‑dose vitamin C: may lower urinary nitrofurantoin levels, reducing effectiveness.

Frequently asked questions

What is Nitrofurantoin used for?+
Nitrofurantoin is an antibiotic indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria. It is commonly prescribed for acute cystitis and other lower urinary tract infections in adult patients.
How does Nitrofurantoin work?+
The drug is reduced by bacterial enzymes to reactive intermediates that damage bacterial DNA, ribosomal proteins, and carbohydrate‑metabolizing enzymes. This multi‑target attack disrupts essential bacterial processes, leading to cell death, especially in urinary pathogens that achieve high concentrations in the urine.
What is the usual dose of Nitrofurantoin?+
The dosage regimen for Nitrofurantoin is determined by the prescribing clinician based on the infection severity, patient renal function, and local guidelines. Patients should follow the prescriber’s instructions and the product label.
Is Nitrofurantoin safe during pregnancy or breastfeeding?+
Nitrofurantoin is classified as pregnancy category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only when clearly needed. Limited amounts are excreted in breast milk; breastfeeding decisions should be made with a healthcare professional.
How do I order Nitrofurantoin from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nitrofurantoin compare with other urinary anti‑infectives?+
Compared with other agents such as trimethoprim‑sulfamethoxazole, Nitrofurantoin has a narrow spectrum focused on common urinary pathogens and achieves high urinary concentrations, making it effective for uncomplicated infections while limiting systemic exposure. Resistance patterns and patient renal function guide the choice of therapy.
What are the storage and handling requirements for Nitrofurantoin?+
Nitrofurantoin tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date.
How is Nitrofurantoin administered?+
Nitrofurantoin is taken orally, usually with food or milk to reduce gastrointestinal irritation. The tablets should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.
What are the most serious risks associated with Nitrofurantoin?+
Serious adverse events include pulmonary toxicity (interstitial lung disease or acute respiratory distress), severe hepatic injury, blood dyscrasias such as agranulocytosis or aplastic anaemia, peripheral neuropathy, and hemolytic anaemia in patients with G6PD deficiency. Prompt medical attention is required if these occur.
Who should not use Nitrofurantoin?+
Nitrofurantoin is contraindicated in patients with severe renal impairment (creatinine clearance <60 mL/min), known hypersensitivity to the drug, and in those with a history of pulmonary toxicity from Nitrofurantoin. Caution is advised in pregnant women, the elderly, and patients with G6PD deficiency.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nitrofurantoin Monohydrate
Route
Oral Use
Manufacturer
Mercury Pharmaceuticals Ltd.
Origin
EU

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