Nitrofurantoin Mercury Pharma (Nitrofurantoin Monohydrate)

Nitrofurantoin, the active ingredient in Nitrofurantoin Mercury Pharma, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections caused by susceptible bacteria, primarily in adult patients, and is commonly prescribed for cystitis.

GNH USA supplies Nitrofurantoin Mercury Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The company adheres to stringent manufacturing standards and provides reliable logistics for global distribution.

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

Uncomplicated urinary tract infection: eliminates susceptible bacteria, relieving symptoms such as dysuria and frequency. Recurrent urinary tract infection prophylaxis: reduces the frequency of future infections when administered as a preventive regimen. Urinary tract infection in pregnancy (when indicated): provides effective treatment for susceptible pathogens under medical supervision.

Nitrofurantoin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea or vomiting - Loss of appetite - Diarrhea or abdominal discomfort - Headache - Metallic taste in the mouth - Mild skin rash

Serious or Rare Side Effects: - Pulmonary toxicity (interstitial pneumonitis or fibrosis) - Hepatic injury (hepatitis or jaundice) - Severe allergic reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis) - Hemolytic anemia in patients with G6PD deficiency - Peripheral neuropathy - Acute kidney injury in susceptible individuals

Before prescribing nitrofurantoin, clinicians should evaluate several safety considerations.

Renal function assessment: evaluate kidney function before initiating therapy and monitor during treatment. Pregnancy considerations: avoid use unless clearly indicated, as safety data are limited. G6PD deficiency: contraindicated due to risk of hemolysis. Elderly patients: monitor for signs of toxicity, especially pulmonary effects. Drug interaction review: assess concomitant medications for potential interactions. Store at room temperature: keep in the original container, protect from moisture and heat.

Nitrofurantoin can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: significantly reduce nitrofurantoin absorption. - Probenecid: increases nitrofurantoin plasma levels, raising toxicity risk.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Fluoroquinolones: additive risk of tendonitis and tendon rupture. - Diuretics: may affect renal clearance, altering drug exposure. - Sulfonamides: overlapping risk of hypersensitivity reactions.