Mutaflor (Escherichia Coli Strain Nissle 1917)

Escherichia coli Nissle 1917, the active ingredient in Mutaflor, is a live bacterial preparation presented as an oral probiotic formulation. It is employed to help maintain remission in individuals with ulcerative colitis by supporting a balanced intestinal microbiota.

GNH USA supplies Mutaflor as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide. The product originates from the European Union market and meets stringent regulatory requirements.

Mutaflor is a probiotic that acts on the gastrointestinal microbiota to support ulcerative colitis management.

- Ulcerative colitis: helps maintain remission in patients with ulcerative colitis.

Adverse reactions are generally mild and gastrointestinal in nature.

Common Side Effects: - Abdominal discomfort: mild pain or cramping. - Flatulence: increased gas production. - Bloating: sensation of abdominal fullness. - Diarrhea: loose stools occurring intermittently. - Nausea: occasional feeling of queasiness. - Headache: transient mild headache.

Serious or Rare Side Effects: - Bacteremia: presence of bacteria in the bloodstream, reported rarely. - Sepsis: systemic infection in immunocompromised individuals. - Allergic reaction: rash, itching, or swelling. - Anaphylaxis: severe, life‑threatening hypersensitivity. - Persistent fever: unexplained elevated temperature. - Severe abdominal pain: intense, prolonged pain requiring medical evaluation.

Safety considerations should be reviewed before initiating therapy.

- Assess immune status: evaluate for severe immunodeficiency before use. - Monitor gastrointestinal symptoms: watch for worsening abdominal pain or diarrhea. - Avoid in severe immunocompromise: contraindicated in patients with profound neutropenia. - Pregnancy and lactation: safety not established; use only if clearly needed. - Discontinue if infection occurs: stop product if systemic infection develops. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Potential interactions with other medicines should be considered.

Major Interactions (Avoid): - Antibiotics: may reduce probiotic viability; avoid concurrent administration. - Immunosuppressants: increased risk of infection; avoid simultaneous use. - Live bacterial vaccines: possible interference with vaccine efficacy.

Moderate Interactions (Monitor Closely): - Antacids: may alter gastric pH and affect bacterial survival. - Corticosteroids: monitor for signs of infection. - Chemotherapy agents: observe for opportunistic infections.