GNH USA

Europe — EMA

Mutaflor (Escherichia Coli Strain Nissle 1917)

GNH USA supplies Mutaflor (Escherichia coli Nissle 1917), a probiotic for ulcerative colitis, inflammatory bowel disease and IBS.

Escherichia Coli Strain Nissle 1917

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What is Escherichia Coli Strain Nissle 1917?

Escherichia coli Nissle 1917, the active ingredient in Mutaflor, is a probiotic presented as a 1×10^9 CFU per sachet oral lyophilized powder for oral use. It is employed to support maintenance of remission in ulcerative colitis and to aid overall gastrointestinal health in related disorders.

GNH USA supplies Mutaflor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Escherichia Coli Strain Nissle 1917 used for?

Mutaflor is a probiotic indicated for several gastrointestinal conditions.

- Ulcerative colitis: helps maintain remission and reduces the frequency of disease flares. - Inflammatory bowel disease: supports gut microbiota balance and may contribute to symptom control. - Irritable bowel syndrome: modulates intestinal flora to alleviate abdominal discomfort and irregular bowel habits.

What are the side effects of Escherichia Coli Strain Nissle 1917?

Adverse reactions to Mutaflor are generally mild and infrequent.

Common Side Effects: - Abdominal discomfort: mild bloating or cramping. - Flatulence: increased gas production. - Diarrhea: transient loose stools. - Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects: - Sepsis: rare systemic infection, particularly in immunocompromised individuals. - Allergic reaction: rash, itching, or swelling. - Bacteremia: presence of bacteria in the blood, extremely uncommon.

What precautions apply to Escherichia Coli Strain Nissle 1917?

Before prescribing Mutaflor, consider the following precautions.

- Immunocompromised patients: assess infection risk before use. - Recent antibiotic therapy: may diminish probiotic colonisation. - Pediatric use: safety not established; use under specialist guidance. - Pregnancy and lactation: safety unknown; weigh potential benefits against risks. - Underlying severe gastrointestinal disease: monitor for signs of bacterial translocation. - Store at ambient temperature: keep sachets in original packaging, protect from moisture and direct sunlight.

What does Escherichia Coli Strain Nissle 1917 interact with?

Mutaflor may interact with certain medications or substances.

Major Interactions (Avoid): - Broad‑spectrum antibiotics: can eradicate the probiotic strain, reducing efficacy. - Immunosuppressive therapy: increased risk of systemic infection.

Moderate Interactions (Monitor Closely): - Antifungal agents: may alter gut flora balance. - Antidiarrheal agents (e.g., loperamide): could affect probiotic transit time. - Live vaccines: theoretical risk of bacterial translocation in immunocompromised hosts.

Frequently asked questions

What is Mutaflor used for?+
Mutaflor is a prescription probiotic containing Escherichia coli Nissle 1917. It is used to maintain remission in ulcerative colitis and to support overall gut health in patients with inflammatory bowel disease and irritable bowel syndrome by helping to rebalance intestinal microbiota.
How does Escherichia coli Nissle 1917 work?+
The Nissle 1917 strain colonises the intestinal lumen, competes with pathogenic bacteria for nutrients and adhesion sites, produces antimicrobial peptides, and interacts with the mucosal immune system. These actions collectively help restore a balanced microbiome and modulate inflammatory pathways.
What is the usual dose of Mutaflor?+
The dosage of Mutaflor is determined by the prescribing clinician based on the individual’s condition, age, and treatment goals. Typical regimens involve one sachet taken orally each day, but the exact schedule should follow the prescriber’s instructions.
Is Mutaflor safe during pregnancy or breastfeeding?+
Safety data for Mutaflor in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Healthcare providers should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing individuals.
How do I order Mutaflor from GNH USA?+
To order Mutaflor, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mutaflor compare with other probiotics or standard therapies?+
Mutaflor contains a single, well‑characterised strain (E. coli Nissle 1917) with documented efficacy in ulcerative colitis remission, whereas many over‑the‑counter probiotics contain mixed strains with variable evidence. Unlike conventional anti‑inflammatory drugs, Mutaflor aims to modify the gut ecosystem rather than directly suppress immune activity.
How should Mutaflor be stored and handled?+
Mutaflor sachets should be stored at ambient temperature, below 25 °C, in their original sealed packaging. Protect them from moisture, excessive heat and direct sunlight to maintain bacterial viability until the point of use.
How is Mutaflor administered?+
Mutaflor is supplied as a lyophilized powder in single‑use sachets. The contents are typically dissolved in a small amount of water or non‑carbonated beverage and taken orally, as directed by the prescribing clinician.
What are the most serious risks to watch for with Mutaflor?+
Although rare, serious risks include systemic infection such as sepsis or bacteremia, especially in immunocompromised patients, and severe allergic reactions presenting as rash, swelling or anaphylaxis. Prompt medical attention is required if any of these symptoms occur.
Who should not use Mutaflor?+
Mutaflor should be avoided in individuals with severe immunosuppression, uncontrolled critical illness, or known hypersensitivity to Escherichia coli Nissle 1917. Caution is also advised for patients with central venous catheters or those receiving intensive chemotherapy until safety is confirmed.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Escherichia Coli Strain Nissle 1917
Route
Oral Use
Manufacturer
Ardeypharm Gmbh
Origin
EU

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