GNH USA

Europe — EMA

Mutaflor (Escherichia Coli Strain Nissle 1917)

GNH USA supplies Mutaflor (Escherichia coli strain Nissle 1917), a probiotic for maintenance of remission in ulcerative colitis.

Escherichia Coli Strain Nissle 1917

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What is Escherichia Coli Strain Nissle 1917?

Escherichia coli strain Nissle 1917, the active ingredient in Mutaflor, is a probiotic presented as an oral preparation for oral use. It is used to support intestinal health and to maintain remission in ulcerative colitis patients. GNH USA supplies Mutaflor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Escherichia Coli Strain Nissle 1917 used for?

Mutaflor is a probiotic that acts on the gastrointestinal tract to help restore a balanced intestinal microbiota. - Ulcerative colitis: helps maintain remission and reduces relapse risk. - Antibiotic‑associated diarrhea: may aid recovery of normal gut flora. - General gut microbiota imbalance: supports restoration of a healthy bacterial ecosystem.

What are the side effects of Escherichia Coli Strain Nissle 1917?

Common Side Effects: - Abdominal discomfort: mild, transient pain. - Flatulence: increased gas production. - Nausea: occasional feeling of queasiness. - Diarrhea: mild loose stools. - Headache: occasional mild headache. Serious or Rare Side Effects: - Sepsis: systemic infection in severely immunocompromised individuals. - Bacteremia: presence of bacteria in the bloodstream. - Allergic reaction: rash, itching, or swelling. - Anaphylaxis: rare severe hypersensitivity requiring emergency care.

What precautions apply to Escherichia Coli Strain Nissle 1917?

Before using Mutaflor, consider the following precautions: - Assess immune status: avoid in patients with severe immunosuppression. - Monitor infection signs: watch for fever, chills, or gastrointestinal upset. - Hypersensitivity: discontinue if allergic reactions occur. - Pregnancy and lactation: consult a healthcare professional before use. - Storage: keep at ambient temperature below 25°C: retain in original packaging and protect from moisture.

What does Escherichia Coli Strain Nissle 1917 interact with?

Mutaflor may interact with other agents as follows: Major Interactions (Avoid): - Broad‑spectrum antibiotics: may diminish probiotic viability and effectiveness. - Immunosuppressive therapy: increased risk of systemic infection. Moderate Interactions (Monitor Closely): - Antacids: can affect bacterial survival in the stomach. - Other probiotic products: potential competition for colonisation sites. - Fermented foods: may alter overall gut microbial balance.

Frequently asked questions

What is Mutaflor used for?+
Mutaflor is a probiotic containing the live bacterial strain Escherichia coli Nissle 1917. It is primarily used to help maintain remission in patients with ulcerative colitis and to support a healthy balance of gut microbiota in various gastrointestinal conditions.
How does Escherichia coli Nissle 1917 work in Mutaflor?+
The strain Nissle 1917 colonises the intestinal lining, where it competes with harmful bacteria for attachment sites, produces substances that inhibit pathogens, and interacts with the immune system to promote a balanced microbial environment and strengthen the gut barrier.
What is the usual dose of Mutaflor?+
The dosage of Mutaflor is determined by the prescribing healthcare professional based on the patient’s condition, age, and clinical response. Patients should follow the specific instructions provided by their prescriber and not alter the regimen without medical advice.
Is Mutaflor safe during pregnancy or breastfeeding?+
Safety data for Mutaflor in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting the product.
How do I order Mutaflor from GNH USA?+
To order Mutaflor, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mutaflor compare with other probiotics?+
Mutaflor contains a single, well‑studied strain (E. coli Nissle 1917) with documented efficacy in ulcerative colitis, whereas many other probiotics are multi‑strain blends with broader but less specific evidence. The choice depends on the clinical indication, regulatory status and physician preference.
What are the storage and handling requirements for Mutaflor?+
Mutaflor should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture. It does not require refrigeration, but exposure to high heat or humidity may reduce bacterial viability.
How is Mutaflor administered?+
Mutaflor is taken orally, usually as a capsule or sachet containing live bacteria. It should be swallowed with water according to the prescriber’s instructions, and may be taken with or without food depending on individual tolerance.
What are the most serious risks associated with Mutaflor?+
The most serious risks include rare cases of systemic infection such as sepsis or bacteremia, particularly in patients with severely compromised immune systems. Prompt medical attention is required if signs of infection, such as fever or chills, develop.
Who should not use Mutaflor?+
Mutaflor is contraindicated in individuals with known hypersensitivity to the product and should be avoided in patients with severe immunosuppression or those at high risk for invasive bacterial infections unless specifically advised by a healthcare professional.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Escherichia Coli Strain Nissle 1917
Route
Oral Use
Manufacturer
Sabora Pharma Oy
Origin
EU

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