GNH USA

Europe — EMA

Merkaptopurin Silver

GNH USA supplies Merkaptopurin Silver (Mercaptopurine), a purine analog antimetabolite for acute lymphoblastic leukemia, chronic myeloid leukemia

Mercaptopurine Monohydrate

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What is Mercaptopurine Monohydrate?

Mercaptopurine, the active ingredient in Merkaptopurin Silver, is a purine analog antimetabolite presented as an oral formulation for oral use. It is employed in the treatment of certain leukemias and inflammatory bowel disease in adult and pediatric patients.

GNH USA supplies Merkaptopurin Silver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

What is Mercaptopurine Monohydrate used for?

Merkaptopurin Silver is used in diseases where inhibition of purine synthesis is therapeutic. - Acute lymphoblastic leukemia: helps achieve remission by suppressing malignant lymphoblast proliferation. - Chronic myeloid leukemia: contributes to disease control by reducing leukemic cell growth. - Inflammatory bowel disease (Crohn's disease, ulcerative colitis): aids in maintaining remission by modulating immune response.

What are the side effects of Mercaptopurine Monohydrate?

Adverse reactions to Merkaptopurin Silver vary in frequency and severity.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Fatigue: decreased energy levels. - Liver enzyme elevation: transient increase in ALT/AST. - Myelosuppression: reduced white blood cell counts.

Serious or Rare Side Effects: - Severe neutropenia: marked drop in neutrophils increasing infection risk. - Hepatotoxicity: significant liver injury with jaundice. - Secondary malignancies: rare development of other cancers.

What precautions apply to Mercaptopurine Monohydrate?

When prescribing Merkaptopurin Silver, clinicians should observe several safety considerations. - Baseline monitoring: obtain complete blood count and liver function tests before initiation. - Dose adjustments: modify dose in patients with renal or hepatic impairment. - Infection risk: monitor for signs of infection due to immunosuppression. - Pregnancy and lactation: avoid use unless benefits outweigh potential risks. - Drug interactions: review concomitant medications for known interactions. - Store at room temperature: keep below 25 °C in the original container, protect from moisture and light.

What does Mercaptopurine Monohydrate interact with?

Mercaptopurine may interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Allopurinol: can increase mercaptopurine toxicity; concurrent use generally avoided. - Azathioprine: additive myelosuppression; avoid combined therapy. - TPMT inhibitors: may raise active metabolite levels, increasing risk of severe toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect; monitor INR. - 5‑Fluorouracil: potential additive bone marrow suppression; observe blood counts. - Sulfonamides: may interfere with metabolism; watch for increased adverse effects.

Frequently asked questions

What is Merkaptopurin Silver used for?+
Merkaptopurin Silver contains mercaptopurine, an oral purine analog antimetabolite. It is prescribed for the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and for maintaining remission in inflammatory bowel disease such as Crohn’s disease and ulcerative colitis. The medication works by suppressing abnormal cell proliferation and modulating the immune system, and it is administered under the supervision of a qualified healthcare professional.
How does mercaptopurine work?+
Mercaptopurine is taken up by cells and metabolized into thio‑guanine nucleotides. These metabolites inhibit the enzyme amidophosphoribosyltransferase, blocking de novo synthesis of purine nucleotides, and they become incorporated into DNA and RNA. The resulting disruption of nucleic acid synthesis leads to cytotoxicity in rapidly dividing cells, including malignant leukemic cells, while also dampening immune cell activity, providing both antineoplastic and immunosuppressive effects.
What is the usual dose of Merkaptopurin Silver?+
The dosage of Merkaptopurin Silver is individualized by the prescribing clinician based on the patient’s age, weight, disease indication, and laboratory parameters. Physicians calculate the appropriate dose, often adjusting it according to therapeutic drug monitoring, renal and hepatic function, and tolerance. Patients should follow the exact dosing instructions provided by their healthcare provider and not alter the regimen without medical advice.
Is Merkaptopurin Silver safe during pregnancy or breastfeeding?+
The safety of mercaptopurine in pregnancy and lactation has not been definitively established, and it is generally classified as contraindicated unless the potential therapeutic benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatment options with their physician, as exposure may be associated with fetal toxicity or neonatal immunosuppression.
How do I order Merkaptopurin Silver from GNH USA?+
To request Merkaptopurin Silver, visit the product page on gnh-usa.com and submit an enquiry specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing a formal quotation. The sales team then replies with pricing, availability, shipping details—including any temperature‑controlled logistics if needed—and assists with the necessary import documentation.
How does Merkaptopurin Silver compare with azathioprine?+
Both mercaptopurine and azathioprine belong to the thiopurine class and share similar mechanisms of inhibiting purine synthesis. Mercaptopurine is the active metabolite of azathioprine, offering a more direct pharmacologic effect. Clinically, dosing strategies differ, and mercaptopurine may provide more predictable plasma levels, whereas azathioprine requires conversion. Choice between them depends on disease indication, patient tolerance, and physician preference.
What are the storage requirements for Merkaptopurin Silver?+
Merkaptopurin Silver should be stored at room temperature, preferably below 25 °C (77 °F). Keep the product in its original packaging to protect it from moisture, light, and excessive heat. Do not refrigerate or freeze the tablets, and ensure the container remains tightly closed when not in use to maintain stability throughout its shelf life.
How is Merkaptopurin Silver administered?+
Merkaptopurin Silver is administered orally, typically as a tablet taken with water. The medication may be taken with or without food, depending on the prescriber’s guidance. Patients should swallow the tablet whole and avoid crushing or chewing it unless specifically instructed. Consistent timing each day helps maintain stable drug levels, and adherence to the prescribed schedule is essential for therapeutic effectiveness.
What are the most serious risks associated with Merkaptopurin Silver?+
The most serious adverse risks include severe myelosuppression leading to neutropenia or pancytopenia, which can increase susceptibility to infections and bleeding; hepatotoxicity presenting as marked liver enzyme elevation or liver failure; and the rare possibility of secondary malignancies such as lymphomas. Prompt monitoring of blood counts and liver function, along with immediate medical attention for signs of infection or liver injury, is critical.
Who should not use Merkaptopurin Silver?+
Merkaptopurin Silver is contraindicated in individuals with known hypersensitivity to mercaptopurine or any component of the formulation. Patients with severe hepatic or renal impairment, active uncontrolled infections, or those receiving other myelosuppressive agents without close monitoring should avoid the drug. Additionally, pregnant or breastfeeding women should not use it unless the prescribing physician determines that the therapeutic benefit outweighs the potential risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Mercaptopurine Monohydrate
Route
Oral Use
Manufacturer
Silver Pharma S.L.
Origin
EU

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