GNH USA

Europe — EMA

Mercaptopurin Silver (Mercaptopurine Monohydrate)

GNH USA supplies Mercaptopurin Silver (Mercaptopurine), a purine analog antimetabolite for acute lymphoblastic leukemia, chronic lymphocytic leukemia

Mercaptopurine Monohydrate

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What is Mercaptopurine Monohydrate?

Mercaptopurine, the active ingredient in Mercaptopurin Silver, is a purine analog antimetabolite presented as an oral formulation for oral use. It is employed in the treatment of certain leukemias and inflammatory bowel diseases in adult and pediatric patients. GNH USA supplies Mercaptopurin Silver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Mercaptopurine Monohydrate used for?

Mercaptopurin Silver is used as a purine‑analog antimetabolite in several hematologic and gastrointestinal disorders. - Acute lymphoblastic leukemia: helps achieve remission by targeting rapidly dividing lymphoblasts. - Chronic lymphocytic leukemia: contributes to disease control through inhibition of malignant B‑cell proliferation. - Inflammatory bowel disease (Crohn's disease, ulcerative colitis): reduces intestinal inflammation and maintains remission in patients with moderate to severe disease.

What are the side effects of Mercaptopurine Monohydrate?

Mercaptopurin Silver may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Vomiting: occasional episodes after dosing. - Decreased appetite: reduced food intake. - Fatigue: feeling of tiredness or low energy.

Serious or Rare Side Effects: - Bone marrow suppression: can lead to anemia, neutropenia, or thrombocytopenia. - Severe infections: opportunistic infections due to immunosuppression. - Liver toxicity: elevated transaminases or hepatitis.

What precautions apply to Mercaptopurine Monohydrate?

When using Mercaptopurin Silver, clinicians should observe several safety measures. - Monitor blood counts: regular CBC to detect marrow suppression early. - Assess liver function: periodic LFTs to identify hepatotoxicity. - Avoid use in pregnancy unless essential: drug is classified as Category D. - Adjust dose in renal impairment: consider reduced dosing in patients with decreased clearance. - Store below 25°C: keep in the original pack, protect from moisture.

What does Mercaptopurine Monohydrate interact with?

Mercaptopurin Silver interacts with several medicines that can alter its safety or efficacy.

Major Interactions (Avoid): - Allopurinol: increases mercaptopurine toxicity and may cause severe myelosuppression. - Azathioprine: additive bone‑marrow suppression when used together. - Warfarin: potentiates anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Methotrexate: combined use may enhance myelosuppression; monitor blood counts closely. - Trimethoprim‑sulfamethoxazole: can increase risk of bone‑marrow suppression; adjust therapy as needed.

Frequently asked questions

What conditions is Mercaptopurin Silver used for?+
Mercaptopurin Silver contains mercaptopurine, a purine analog antimetabolite indicated for acute lymphoblastic leukemia, chronic lymphocytic leukemia, and inflammatory bowel disease such as Crohn's disease and ulcerative colitis. It works by inhibiting the growth of rapidly dividing cells in these disorders.
How does mercaptopurine work in the body?+
After oral intake, mercaptopurine is metabolised inside cells to thioinosine monophosphate, which blocks the synthesis of new purine nucleotides. This disruption prevents DNA and RNA formation, leading to selective cytotoxicity of fast‑dividing malignant or immune cells.
What is the usual dose of Mercaptopurin Silver?+
The dosage of Mercaptopurin Silver is individualized by the prescribing clinician based on the specific indication, patient age, weight, renal function and therapeutic response. Only a qualified health professional should determine the appropriate regimen.
Is Mercaptopurin Silver safe during pregnancy or breastfeeding?+
Mercaptopurin Silver is classified as Pregnancy Category D, indicating evidence of fetal risk. It should be used in pregnancy only when the potential benefit justifies the risk. Breastfeeding is not recommended because the drug is excreted in milk and may affect the infant.
How do I order Mercaptopurin Silver from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mercaptopurin Silver compare with other treatments for leukemia?+
Mercaptopurin Silver belongs to the thiopurine class, offering an oral alternative to intravenous chemotherapy agents. Compared with newer targeted therapies, it is less expensive but may have a broader toxicity profile, requiring regular monitoring of blood counts and liver function.
What are the storage requirements for Mercaptopurin Silver?+
Mercaptopurin Silver should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining a stable room‑temperature environment helps preserve the tablet’s potency throughout its shelf life.
How is Mercaptopurin Silver administered?+
The product is taken orally, usually with water. The exact timing relative to meals and other medications is determined by the prescriber to optimise absorption and minimize interactions.
What are the most serious risks associated with Mercaptopurin Silver?+
The most serious risks include bone‑marrow suppression leading to severe anemia, neutropenia or thrombocytopenia, life‑threatening infections, and hepatotoxicity. Patients should be monitored closely for signs of infection, bleeding or liver dysfunction.
Who should not use Mercaptopurin Silver?+
Mercaptopurin Silver is contraindicated in patients with known hypersensitivity to mercaptopurine or any component of the formulation, in those with severe hepatic impairment, and in pregnant women unless the therapeutic benefit outweighs the fetal risk. It should also be avoided in individuals with active, uncontrolled infections.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Mercaptopurine Monohydrate
Route
Oral Use
Manufacturer
Silver Pharma S.L.
Origin
EU

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