GNH USA

Europe — EMA

Mercaptopurine Silver Pharma

GNH USA supplies Mercaptopurine Silver Pharma (Mercaptopurine), a thiopurine antimetabolite for acute lymphoblastic leukemia, Crohn's disease and ulcerative

Mercaptopurine Monohydrate

Request sourcing

1
Pack/s

What is Mercaptopurine Monohydrate?

Mercaptopurine, the active ingredient in Mercaptopurine Silver Pharma, is a thiopurine antimetabolite presented as an oral tablet for oral use. It is employed in the treatment of acute lymphoblastic leukemia and as an immunosuppressant in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis, primarily in pediatric and adult patients requiring disease‑modifying therapy.

GNH USA supplies Mercaptopurine Silver Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide.

What is Mercaptopurine Monohydrate used for?

Mercaptopurine acts on rapidly dividing cells and on immune pathways, making it useful in hematologic malignancies and inflammatory bowel disorders.

Acute lymphoblastic leukemia: induces remission by inhibiting DNA synthesis in leukemic lymphoblasts. Crohn's disease: reduces intestinal inflammation and helps maintain clinical remission. Ulcerative colitis: contributes to disease control and prolongs remission periods.

What are the side effects of Mercaptopurine Monohydrate?

Mercaptopurine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting. - Decreased appetite. - Mild leukopenia or neutropenia. - Fatigue. - Skin rash.

Serious or Rare Side Effects: - Severe bone‑marrow suppression leading to pancytopenia. - Hepatotoxicity with elevated liver enzymes. - Acute pancreatitis. - Life‑threatening infections due to immunosuppression. - Severe hypersensitivity reactions including Stevens‑Johnson syndrome.

What precautions apply to Mercaptopurine Monohydrate?

When using Mercaptopurine, several safety measures should be observed.

Monitor blood counts regularly: detect early marrow suppression. Assess liver function: identify potential hepatotoxicity. Adjust dose in renal impairment: reduce exposure in decreased clearance. Avoid use in known hypersensitivity: discontinue if allergic reaction occurs. Counsel patients on infection risk: advise prompt reporting of fever or signs of infection. Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Mercaptopurine Monohydrate interact with?

Mercaptopurine interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid): - Allopurinol: may increase mercaptopurine toxicity. - Azathioprine: additive myelosuppression. - Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely): - Warfarin: potential alteration of anticoagulant effect. - Methotrexate: combined bone‑marrow suppression risk.

Frequently asked questions

What is Mercaptopurine Silver Pharma used for?+
Mercaptopurine Silver Pharma contains the antimetabolite mercaptopurine and is used to treat acute lymphoblastic leukemia and to manage inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. It works by suppressing the rapid growth of malignant cells and modulating the immune response in chronic intestinal inflammation.
How does mercaptopurine work?+
After oral absorption, mercaptopurine is converted inside cells to thio‑inosine monophosphate, which blocks the synthesis of purine nucleotides. This inhibition reduces DNA and RNA production, limiting the proliferation of rapidly dividing cells, including leukemic lymphoblasts and activated immune cells involved in intestinal inflammation.
What is the usual dose of mercaptopurine?+
The dose of mercaptopurine is individualized and set by the prescribing clinician based on the patient’s age, weight, disease indication, and laboratory monitoring results. Dosage adjustments are made according to blood count and liver function tests to balance efficacy with safety.
Is mercaptopurine safe during pregnancy or breastfeeding?+
Data on mercaptopurine use in pregnancy and lactation are limited. Because the drug can cross the placenta and is excreted in breast milk, it is generally avoided unless the potential benefit to the mother outweighs the possible risk to the fetus or infant. Decisions should be made in consultation with a specialist.
How do I order Mercaptopurine Silver Pharma from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.
How does mercaptopurine compare with the main alternative drug or class?+
Azathioprine is the most common alternative within the thiopurine class. Both drugs share a similar mechanism of inhibiting purine synthesis, but mercaptopurine is often preferred for acute lymphoblastic leukemia because of its more direct antineoplastic activity, whereas azathioprine is frequently used for long‑term immunosuppression in transplant and autoimmune settings.
What are the storage and handling requirements for Mercaptopurine Silver Pharma?+
Mercaptopurine tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.
How is Mercaptopurine Silver Pharma administered?+
The medication is taken orally, usually with a glass of water. It may be prescribed with or without food, depending on the clinician’s guidance. Patients should follow the exact schedule provided by their healthcare professional and not alter the timing without medical advice.
What are the most serious risks to watch for while taking mercaptopurine?+
The most critical risks include severe bone‑marrow suppression leading to pancytopenia, hepatotoxicity with possible liver failure, acute pancreatitis, and life‑threatening infections due to immunosuppression. Prompt medical attention is required if symptoms such as persistent fever, jaundice, severe abdominal pain, or unusual bleeding occur.
Who should not use mercaptopurine?+
Mercaptopurine is contraindicated in individuals with known hypersensitivity to the drug or any thiopurine, in patients with severe bone‑marrow failure, and in those with active, uncontrolled infections. Caution is also advised for patients with significant hepatic or renal impairment, and it should be avoided in pregnant or breastfeeding women unless absolutely necessary.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Mercaptopurine Monohydrate
Route
Oral Use
Manufacturer
Silver Pharma S.L.
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU