GNH USA

Europe — EMA

Mercaptopurina Silver (Mercaptopurine Monohydrate)

GNH USA supplies Mercaptopurina Silver (Mercaptopurine), an antimetabolite for ALL and inflammatory bowel disease.

Mercaptopurine Monohydrate

Request sourcing

1
Pack/s

What is Mercaptopurine Monohydrate?

Mercaptopurine, the active ingredient in Mercaptopurina Silver, is an antimetabolite presented as a tablet for oral use. It is used to treat acute lymphoblastic leukemia, chronic lymphocytic leukemia, inflammatory bowel disease and other autoimmune disorders.

GNH USA supplies Mercaptopurina Silver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

What is Mercaptopurine Monohydrate used for?

Mercaptopurine acts on rapidly dividing cells and modulates immune function, making it useful in several hematologic and inflammatory conditions. - Acute lymphoblastic leukemia (ALL): helps achieve remission and maintain disease control. - Chronic lymphocytic leukemia (CLL): slows disease progression and supports long‑term management. - Inflammatory bowel disease (Crohn's disease, ulcerative colitis): reduces intestinal inflammation and helps maintain remission. - Autoimmune disorders (e.g., rheumatoid arthritis): suppresses abnormal immune activity.

What are the side effects of Mercaptopurine Monohydrate?

Adverse reactions may occur and should be monitored during therapy.

Common Side Effects: - Nausea and vomiting - Loss of appetite - Mild diarrhea - Transient liver enzyme elevation - Fatigue or weakness - Mild rash or itching

Serious or Rare Side Effects: - Severe bone marrow suppression (neutropenia, anemia, thrombocytopenia) - Hepatotoxicity with marked liver enzyme rise - Pancreatitis - Severe infections due to immunosuppression - Hypersensitivity reactions including Stevens‑Johnson syndrome

What precautions apply to Mercaptopurine Monohydrate?

Before initiating therapy, patients should be evaluated for baseline blood counts and liver function. - Monitor blood counts regularly: watch for neutropenia, anemia, and thrombocytopenia. - Assess liver function: check ALT, AST, and bilirubin levels. - Screen for thiopurine methyltransferase (TPMT) activity when possible to reduce toxicity risk. - Avoid use in patients with known hypersensitivity to mercaptopurine. - Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

What does Mercaptopurine Monohydrate interact with?

Mercaptopurine may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Allopurinol: can increase mercaptopurine toxicity; dose adjustment required. - Azathioprine: additive myelosuppression risk. - Methotrexate: heightened bone marrow suppression.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, monitor INR. - Oral contraceptives: reduced effectiveness, consider alternative contraception. - Antacids containing magnesium or aluminum: may affect absorption, separate administration times.

Frequently asked questions

What conditions is Mercaptopurina Silver used for?+
Mercaptopurina Silver contains mercaptopurine, which is prescribed for acute lymphoblastic leukemia, chronic lymphocytic leukemia, inflammatory bowel disease such as Crohn's disease and ulcerative colitis, and certain autoimmune disorders where immune suppression is needed.
How does mercaptopurine work in the body?+
Mercaptopurine is metabolized inside cells to thioguanine nucleotides that block purine synthesis. This interferes with DNA and RNA formation, limiting the proliferation of rapidly dividing immune and cancer cells and thereby reducing disease activity.
What is the usual dose of Mercaptopurina Silver?+
The specific dose of Mercaptopurina Silver is determined by the prescribing clinician based on the patient’s condition, weight, age, and laboratory parameters. Dosage regimens are individualized and should follow the prescriber’s instructions.
Is Mercaptopurina Silver safe during pregnancy or breastfeeding?+
Safety of mercaptopurine in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Mercaptopurina Silver from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mercaptopurina Silver compare with azathioprine?+
Both mercaptopurine and azathioprine are thiopurine immunosuppressants, but mercaptopurine is the active metabolite of azathioprine. Mercaptopurine may have a more predictable pharmacokinetic profile, while azathioprine requires conversion to mercaptopurine in the body.
What are the storage requirements for Mercaptopurina Silver?+
Mercaptopurina Silver should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight to maintain stability.
How is Mercaptopurina Silver administered?+
The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their healthcare provider.
What are the most serious risks associated with Mercaptopurina Silver?+
The most serious risks include severe bone marrow suppression leading to infections or bleeding, significant liver toxicity, pancreatitis, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Regular monitoring is essential to detect these complications early.
Who should not use Mercaptopurina Silver?+
Patients with known hypersensitivity to mercaptopurine, those with severe liver disease, or individuals with existing severe bone marrow suppression should avoid using Mercaptopurina Silver. Contraindications should be confirmed by a qualified clinician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Mercaptopurine Monohydrate
Route
Oral Use
Manufacturer
Silver Pharma S.L.
Origin
EU

Related products

Hanixol

Hanixol

Mercaptopurine Monohydrate

Fontus Health
EU
Mercaptopurin Orion

Mercaptopurin Orion

Mercaptopurine Monohydrate

Orion Corporation
EU
Mercaptopurin Silver

Mercaptopurin Silver

Mercaptopurine Monohydrate

Silver Pharma S.L.
EU
Mercaptopurin Silver Pharma

Mercaptopurin Silver Pharma

Mercaptopurine Monohydrate

Silver Pharma S.L.
EU