Mercaptopurina Silver

Mercaptopurine, the active ingredient in Mercaptopurina Silver, is an antimetabolite presented as a tablet for oral use. It is used to treat acute lymphoblastic leukemia, chronic lymphocytic leukemia, inflammatory bowel disease and other autoimmune disorders.

GNH USA supplies Mercaptopurina Silver as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Mercaptopurine acts on rapidly dividing cells and modulates immune function, making it useful in several hematologic and inflammatory conditions. - Acute lymphoblastic leukemia (ALL): helps achieve remission and maintain disease control. - Chronic lymphocytic leukemia (CLL): slows disease progression and supports long‑term management. - Inflammatory bowel disease (Crohn's disease, ulcerative colitis): reduces intestinal inflammation and helps maintain remission. - Autoimmune disorders (e.g., rheumatoid arthritis): suppresses abnormal immune activity.

Adverse reactions may occur and should be monitored during therapy.

Common Side Effects: - Nausea and vomiting - Loss of appetite - Mild diarrhea - Transient liver enzyme elevation - Fatigue or weakness - Mild rash or itching

Serious or Rare Side Effects: - Severe bone marrow suppression (neutropenia, anemia, thrombocytopenia) - Hepatotoxicity with marked liver enzyme rise - Pancreatitis - Severe infections due to immunosuppression - Hypersensitivity reactions including Stevens‑Johnson syndrome

Before initiating therapy, patients should be evaluated for baseline blood counts and liver function. - Monitor blood counts regularly: watch for neutropenia, anemia, and thrombocytopenia. - Assess liver function: check ALT, AST, and bilirubin levels. - Screen for thiopurine methyltransferase (TPMT) activity when possible to reduce toxicity risk. - Avoid use in patients with known hypersensitivity to mercaptopurine. - Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Mercaptopurine may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Allopurinol: can increase mercaptopurine toxicity; dose adjustment required. - Azathioprine: additive myelosuppression risk. - Methotrexate: heightened bone marrow suppression.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, monitor INR. - Oral contraceptives: reduced effectiveness, consider alternative contraception. - Antacids containing magnesium or aluminum: may affect absorption, separate administration times.