GNH USA

Europe — EMA

Meclon (Clotrimazole, Metronidazole)

GNH USA supplies Meclon (Clotrimazole, Metronidazole), a vaginal anti‑infective for vulvovaginal candidiasis, bacterial vaginosis and mixed infections.

Clotrimazole, Metronidazole

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What is Clotrimazole, Metronidazole?

Clotrimazole and Metronidazole, the active ingredient in Meclon, is an antifungal and antiprotozoal combination presented as a vaginal formulation for vaginal use. It treats vulvovaginal candidiasis, bacterial vaginosis and mixed vaginal infections in adult women.

GNH USA supplies Meclon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clotrimazole, Metronidazole used for?

Meclon combines an antifungal and antiprotozoal agent to treat common vaginal infections.

Vulvovaginal candidiasis: restores normal flora by eliminating Candida species and relieves itching and discharge. Bacterial vaginosis: eradicates anaerobic bacteria, reducing malodour and discharge. Mixed vaginal infections: simultaneously targets fungal and bacterial pathogens for comprehensive symptom control.

What are the side effects of Clotrimazole, Metronidazole?

Adverse reactions may occur with vaginal use of Meclon.

Common Side Effects: - Vaginal irritation or burning sensation - Mild itching or redness - Increased vaginal discharge - Light‑headedness or headache

Serious or Rare Side Effects: - Allergic reaction such as rash, swelling, or hives - Severe vaginal ulceration or necrosis - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Liver enzyme elevation or hepatitis - Anaphylaxis or severe dizziness

What precautions apply to Clotrimazole, Metronidazole?

Use Meclon only under medical supervision and observe the following precautions.

Assess for known hypersensitivity to clotrimazole, metronidazole or any excipients. Avoid use in the presence of active vaginal ulceration or severe inflammation. Do not exceed the prescribed duration of therapy. Monitor for secondary infections or persistent symptoms. Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Clotrimazole, Metronidazole interact with?

Meclon may interact with other medicines; consider the following.

Major Interactions (Avoid): - Alcohol: may cause a disulfiram‑like reaction with metronidazole. - Systemic azole antifungals: can increase clotrimazole levels and toxicity. - Warfarin: metronidazole may potentiate anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Oral contraceptives: metronidazole may reduce hormonal efficacy. - Anticonvulsants (e.g., phenytoin, carbamazepine): enzyme induction may lower metronidazole concentrations. - Topical steroids: may mask local irritation or infection signs.

Frequently asked questions

What conditions is Meclon used to treat?+
Meclon is indicated for the treatment of vulvovaginal candidiasis, bacterial vaginosis, and mixed vaginal infections where both fungal and anaerobic bacterial pathogens are present. It is applied locally to the vagina to relieve symptoms such as itching, discharge, and odor.
How does the combination of clotrimazole and metronidazole work?+
Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, blocking ergosterol synthesis and disrupting the cell membrane of Candida species. Metronidazole is reduced inside anaerobic bacteria to reactive nitro radicals that damage DNA and inhibit nucleic acid synthesis, leading to bacterial cell death. Together they provide broad‑spectrum activity against both yeast and anaerobic bacteria.
What is the usual dose of Meclon?+
The dosage regimen for Meclon is determined by the prescribing healthcare professional based on the specific infection, severity, and patient factors. Patients should follow the exact instructions provided on the prescription label and by their clinician.
Is Meclon safe to use during pregnancy or breastfeeding?+
Safety data for Meclon in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks before prescribing to pregnant or nursing women. Women should discuss their individual situation with a qualified professional.
How do I order Meclon from GNH USA?+
To request Meclon, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Meclon compare with other vaginal anti‑infectives?+
Compared with single‑agent products, Meclon offers a dual mechanism that simultaneously targets fungal and anaerobic bacterial pathogens, making it suitable for mixed infections. Alternatives may require separate antifungal and antibacterial treatments, potentially increasing cost and complexity of therapy.
What are the storage and handling requirements for Meclon?+
Meclon should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiration date.
How is Meclon administered?+
Meclon is applied intravaginally as directed by a healthcare professional. The patient typically inserts the prescribed amount into the vagina using the supplied applicator or as instructed, and remains lying down for a short period to ensure proper distribution.
What are the most serious risks associated with Meclon?+
Serious risks include severe allergic reactions such as rash, swelling, or anaphylaxis, as well as rare but serious conditions like Stevens‑Johnson syndrome, severe vaginal ulceration, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience any of these symptoms.
Who should not use Meclon?+
Meclon should not be used by individuals with a known hypersensitivity to clotrimazole, metronidazole, or any formulation excipients. It is also contraindicated in the presence of active vaginal ulceration or severe inflammation until the underlying condition is resolved.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Clotrimazole, Metronidazole
Route
Vaginal Use
Manufacturer
Alfasigma S.P.A.
Origin
EU

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