Makro-Albumon

Human Albumin, the active ingredient in Makro-Albumon, is a plasma protein presented as a solution for injection for intravenous use. It expands plasma volume and is used to treat hypovolemia, shock, burns, and hypoalbuminemia in hospitalized patients.

GNH USA supplies Makro-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Makro-Albumon is a plasma protein volume expander indicated for conditions where intravascular volume needs restoration.

- Hypovolemia: restores intravascular volume and improves tissue perfusion. - Shock: supports circulatory stability by increasing oncotic pressure. - Burns: assists fluid resuscitation and maintains plasma oncotic balance. - Hypoalbuminemia: replenishes deficient albumin levels to improve oncotic pressure.

Adverse reactions may occur following intravenous administration of Makro-Albumon.

Common Side Effects: - Fever or chills during infusion. - Headache. - Nausea or vomiting. - Transient hypertension. - Transient hypotension. - Mild rash at infusion site.

Serious or Rare Side Effects: - Anaphylactic or severe allergic reaction. - Volume overload leading to pulmonary edema. - Thromboembolic events. - Hemolysis. - Acute renal failure. - Severe hypotension or cardiovascular collapse.

Makro-Albumon should be used with careful clinical assessment and monitoring.

- Assess volume status: avoid in patients with existing fluid overload. - Monitor cardiac function: caution in heart failure or compromised cardiac output. - Check serum albumin levels: adjust dosing based on laboratory values. - Observe for infusion reactions: be prepared to manage anaphylaxis. - Evaluate renal function: use cautiously in renal impairment. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Potential drug interactions should be reviewed before administering Makro-Albumon.

Major Interactions (Avoid): - Concurrent use with other plasma expanders: increased risk of volume overload. - High‑dose diuretics: may exacerbate hypovolemia.

Moderate Interactions (Monitor Closely): - Drugs highly bound to albumin (e.g., warfarin, phenytoin): may alter plasma concentrations. - ACE inhibitors or ARBs: monitor blood pressure closely. - Corticosteroids: increased risk of fluid retention. - Nephrotoxic agents: monitor renal function.