Macro-Albumon

Human Albumin, the active ingredient in Macro-Albumon, is a biologic presented as a sterile solution for intravenous use. It is employed to expand plasma volume in patients with acute fluid loss, such as during surgery, trauma, or severe burns.

GNH USA supplies Macro-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Macro-Albumon, a human albumin macroaggregate, is used to restore intravascular volume in conditions associated with plasma loss.

- Hypovolemia: increases circulating plasma volume to improve tissue perfusion. - Major surgery: maintains hemodynamic stability during operative blood loss. - Severe burns: supports fluid resuscitation and reduces edema. - Massive hemorrhage: rapidly expands intravascular volume to stabilize blood pressure.

Common Side Effects: - Fever or chills - Mild hypotension - Headache - Nausea or vomiting - Localized rash at infusion site - Transient dizziness

Serious or Rare Side Effects: - Anaphylactic reaction - Severe volume overload leading to pulmonary edema - Hemolysis - Acute renal failure - Infection transmission risk - Thromboembolic events

Macro-Albumon should be administered under careful clinical monitoring. - Assess volume status: evaluate fluid balance before infusion. - Monitor vital signs: watch for hypotension or hypertension during administration. - Use cautiously in heart failure: risk of volume overload. - Avoid in known albumin allergy: discontinue if hypersensitivity occurs. - Observe for infection signs: ensure product sterility. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Potential drug interactions require clinical awareness.

Major Interactions (Avoid): - Concurrent high‑dose diuretics: may precipitate severe hypotension. - Other volume expanders (e.g., hydroxyethyl starch): increase risk of overload. - Anticoagulants: may enhance bleeding risk due to dilutional effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: monitor blood pressure for additive hypotensive effect. - Vasopressors: adjust dosing as albumin may alter vascular responsiveness. - Blood products: coordinate timing to avoid volume excess. - Other colloids: assess cumulative oncotic load.