GNH USA

Europe — EMA

Macrobid (Nitrofurantoin Monohydrate)

GNH USA supplies Macrobid (Nitrofurantoin), a nitrofuran antibiotic for uncomplicated urinary tract infections. Request a quote for supply to hospitals.

Nitrofurantoin Monohydrate

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What is Nitrofurantoin Monohydrate?

Nitrofurantoin, the active ingredient in Macrobid, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections caused by susceptible bacteria in adult patients.

GNH USA supplies Macrobid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nitrofurantoin Monohydrate used for?

Macrobid (nitrofurantoin) is used to manage infections of the urinary tract caused by susceptible organisms.

Uncomplicated urinary tract infection (cystitis): eradicates the causative bacteria and relieves symptoms. Prevention of recurrent urinary tract infection: reduces the frequency of future episodes in susceptible individuals. Lower urinary tract infection caused by susceptible organisms: provides bacterial clearance and clinical cure.

What are the side effects of Nitrofurantoin Monohydrate?

Common Side Effects: - Nausea - Diarrhea - Headache - Loss of appetite

Serious or Rare Side Effects: - Pulmonary toxicity (interstitial pneumonitis) - Hepatotoxicity (liver injury) - Severe allergic reaction (anaphylaxis)

What precautions apply to Nitrofurantoin Monohydrate?

Precautions should be observed when prescribing nitrofurantoin. - Renal function assessment: avoid use in patients with severely impaired renal function. - Pregnancy considerations: category B, but avoid use in late pregnancy due to potential fetal harm. - G6PD deficiency: monitor for hemolytic anemia. - Hepatic disease: use with caution in patients with liver impairment. - Store at room temperature: keep in the original container, protect from moisture.

What does Nitrofurantoin Monohydrate interact with?

Nitrofurantoin may interact with several medicines.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: increases nitrofurantoin plasma concentrations. - Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - Vitamin C supplements: may increase urinary acidity and affect drug activity. - Diuretics: can alter urinary concentration and affect efficacy. - NSAIDs: concurrent use may increase risk of renal impairment.

Frequently asked questions

What is Macrobid used for?+
Macrobid contains nitrofurantoin, an antibiotic indicated for the treatment of uncomplicated urinary tract infections (cystitis) caused by susceptible bacteria in adult patients.
How does nitrofurantoin work?+
Nitrofurantoin is reduced by bacterial enzymes to reactive metabolites that damage bacterial DNA, ribosomal proteins and carbohydrate‑metabolizing enzymes, resulting in bacterial cell death.
What is the usual dose of Macrobid?+
The dosage of Macrobid is determined by the prescribing clinician based on the patient’s condition, renal function and local treatment guidelines. Patients should follow the prescriber’s instructions.
Is Macrobid safe during pregnancy or breastfeeding?+
Nitrofurantoin is classified as pregnancy category B. It is generally avoided in late pregnancy because of potential fetal risks. Limited data are available for breastfeeding; the prescriber should weigh benefits against possible risks.
How do I order Macrobid from GNH USA?+
Enquiries can be submitted on the product page at gnh-usa.com by specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.
How does Macrobid compare with other urinary anti‑infectives?+
Macrobid (nitrofurantoin) is a nitrofuran antibiotic that concentrates in urine, making it effective for lower urinary tract infections. Compared with trimethoprim‑sulfamethoxazole or fluoroquinolones, nitrofurantoin has a narrower spectrum but a lower risk of promoting resistance and is often preferred for uncomplicated cystitis.
How should Macrobid be stored and handled?+
Store Macrobid tablets at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children.
How is Macrobid administered?+
Macrobid is taken orally, usually with food or a full glass of water to improve absorption and reduce gastrointestinal irritation. The exact schedule is set by the prescriber.
What are the most serious risks associated with Macrobid?+
Serious adverse reactions include pulmonary toxicity (interstitial pneumonitis), hepatotoxicity, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience breathing difficulties, rash, or jaundice.
Who should not use Macrobid?+
Macrobid should be avoided in patients with severe renal impairment (creatinine clearance <30 mL/min), known hypersensitivity to nitrofurantoin, G6PD deficiency, or in late pregnancy. Clinicians must assess individual risk before prescribing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nitrofurantoin Monohydrate
Route
Oral Use
Manufacturer
Mercury Pharmaceuticals Ltd.
Origin
EU

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