Macrobid

Nitrofurantoin, the active ingredient in Macrobid, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections caused by susceptible bacteria in adult patients.

GNH USA supplies Macrobid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Macrobid (nitrofurantoin) is used to manage infections of the urinary tract caused by susceptible organisms.

Uncomplicated urinary tract infection (cystitis): eradicates the causative bacteria and relieves symptoms. Prevention of recurrent urinary tract infection: reduces the frequency of future episodes in susceptible individuals. Lower urinary tract infection caused by susceptible organisms: provides bacterial clearance and clinical cure.

Common Side Effects: - Nausea - Diarrhea - Headache - Loss of appetite

Serious or Rare Side Effects: - Pulmonary toxicity (interstitial pneumonitis) - Hepatotoxicity (liver injury) - Severe allergic reaction (anaphylaxis)

Precautions should be observed when prescribing nitrofurantoin. - Renal function assessment: avoid use in patients with severely impaired renal function. - Pregnancy considerations: category B, but avoid use in late pregnancy due to potential fetal harm. - G6PD deficiency: monitor for hemolytic anemia. - Hepatic disease: use with caution in patients with liver impairment. - Store at room temperature: keep in the original container, protect from moisture.

Nitrofurantoin may interact with several medicines.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: increases nitrofurantoin plasma concentrations. - Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - Vitamin C supplements: may increase urinary acidity and affect drug activity. - Diuretics: can alter urinary concentration and affect efficacy. - NSAIDs: concurrent use may increase risk of renal impairment.