GNH USA

Europe — EMA

Lanvis

GNH USA supplies Lanvis (Tioguanine), a thiopurine for acute lymphoblastic leukemia, chronic myeloid leukemia and inflammatory bowel disease.

Tioguanine

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What is Tioguanine?

Tioguanine, the active ingredient in Lanvis, is a thiopurine presented as an oral formulation for oral use. It is employed in the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia and inflammatory bowel disease in appropriate patients.

GNH USA supplies Lanvis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Tioguanine used for?

Lanvis, a thiopurine, is used in hematologic malignancies and immune‑mediated gastrointestinal disease.

Acute lymphoblastic leukemia: helps achieve remission by targeting rapidly dividing lymphoid cells. Chronic myeloid leukemia: contributes to disease control by inhibiting leukemic proliferation. Inflammatory bowel disease: reduces intestinal inflammation and maintains remission in selected patients.

What are the side effects of Tioguanine?

Adverse reactions may occur with Tioguanine therapy.

Common Side Effects: - Nausea - Vomiting - Diarrhea - Fatigue - Mild elevation of liver enzymes - Decreased white‑blood‑cell count

Serious or Rare Side Effects: - Severe bone‑marrow suppression (aplastic anemia) - Hepatotoxicity, including hepatic failure - Pancreatitis - Life‑threatening infections - Secondary malignancies - Severe hypersensitivity reactions such as Stevens‑Johnson syndrome

What precautions apply to Tioguanine?

Careful monitoring and patient counseling are essential when using Tioguanine. - Monitor blood counts: perform regular CBC to detect myelosuppression. - Assess liver function: check hepatic enzymes before and during therapy. - Screen for infections: evaluate for active infections prior to initiation. - Avoid use in patients with known hypersensitivity to thiopurines. - Pregnancy and lactation: discuss risks with prescriber; use only if benefits outweigh risks. - Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

What does Tioguanine interact with?

Tioguanine may interact with several medicines; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid): - Allopurinol: may increase Tioguanine toxicity. - Azathioprine: additive myelosuppression. - Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely): - 5‑Fluorouracil: increased hematologic toxicity. - Methotrexate: overlapping bone‑marrow suppression. - Rituximab: possible heightened immunosuppression.

Frequently asked questions

What is Lanvis used for?+
Lanvis contains Tioguanine, a thiopurine indicated for the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and certain cases of inflammatory bowel disease where immunosuppression is required.
How does Tioguanine work?+
Tioguanine is converted inside cells to thioguanine nucleotides, which block purine synthesis and become incorporated into DNA and RNA. This disrupts nucleic‑acid function, leading to cytotoxicity of rapidly dividing cells and suppression of immune‑cell proliferation.
What is the usual dose of Lanvis?+
The dose of Lanvis is individualized. A qualified prescriber determines the appropriate amount and schedule based on the patient’s diagnosis, weight, renal and hepatic function, and response to therapy.
Is Lanvis safe in pregnancy or breastfeeding?+
Safety data for Tioguanine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Lanvis from GNH USA?+
To order Lanvis, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Lanvis compare with the main alternative drug or class?+
The primary alternative to Tioguanine is azathioprine, another thiopurine. Both share a similar mechanism of inhibiting purine synthesis, but Tioguanine often provides more predictable pharmacokinetics and may be preferred in patients who do not tolerate azathioprine or require a different toxicity profile.
How should Lanvis be stored and handled?+
Lanvis should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.
How is Lanvis administered?+
Lanvis is administered orally. The tablets (or other oral dosage form) are taken with water, usually on an empty stomach or as directed by the prescribing clinician, to ensure consistent absorption.
What are the most serious risks to watch for while taking Lanvis?+
The most serious risks include severe bone‑marrow suppression leading to anemia, neutropenia or thrombocytopenia; hepatotoxicity that can progress to liver failure; life‑threatening infections due to immunosuppression; and rare but severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
Who should not use Lanvis?+
Lanvis should be avoided in patients with known hypersensitivity to Tioguanine or other thiopurines, those with severe hepatic impairment, active uncontrolled infections, or in individuals for whom the risk–benefit balance is unfavorable, such as certain pregnant or breastfeeding women without specialist guidance.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tioguanine
Route
Oral Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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