GNH USA

Europe — EMA

Lanvis

GNH USA supplies Lanvis (Tioguanine), a purine analog immunosuppressant for lymphoblastic leukemia, myeloid leukemia and organ transplantation.

Tioguanine

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What is Tioguanine?

Tioguanine, the active ingredient in Lanvis, is a purine analog presented as an oral tablet for oral use. It is used as an immunosuppressant in acute lymphoblastic leukemia, chronic myeloid leukemia, and organ transplantation. GNH USA supplies Lanvis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Tioguanine used for?

Lanvis (tioguanine) is employed in hematologic malignancies and transplant immunosuppression. Acute lymphoblastic leukemia: helps achieve remission by targeting proliferating lymphoblasts. Chronic myeloid leukemia: contributes to disease control through inhibition of leukemic cell proliferation. Organ transplantation: provides immunosuppression to prevent graft rejection.

What are the side effects of Tioguanine?

Common Side Effects: - Nausea and vomiting - Diarrhea - Fever or chills - Fatigue or weakness - Alopecia (hair loss) - Mild liver enzyme elevation

Serious or Rare Side Effects: - Severe bone‑marrow suppression (neutropenia, thrombocytopenia, anemia) - Hepatotoxicity leading to liver dysfunction - Opportunistic infections due to immunosuppression - Secondary malignancies - Severe hypersensitivity reactions

What precautions apply to Tioguanine?

Patients receiving Lanvis require careful monitoring and individualized risk assessment. - Monitor blood counts: perform regular CBC to detect myelosuppression. - Assess liver function: periodic LFTs are recommended. - Evaluate renal function: adjust use if significant impairment exists. - Avoid use in active severe infections: increased risk of complications. - Pregnancy: generally contraindicated unless benefits outweigh risks. - Store at ambient temperature: keep below 25°C, protect from moisture and light.

What does Tioguanine interact with?

Tioguanine may interact with several concomitant medicines. Major Interactions (Avoid): - Allopurinol: increased risk of bone‑marrow toxicity. - Azathioprine: additive myelosuppressive effect. - Warfarin: enhanced anticoagulant activity. Moderate Interactions (Monitor Closely): - NSAIDs: potential renal function impact. - Fluoroquinolones: increased gastrointestinal irritation.

Frequently asked questions

What is Lanvis used for?+
Lanvis contains tioguanine, which is indicated for the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and as an immunosuppressant in organ transplantation to prevent graft rejection. It is prescribed by oncologists and transplant physicians as part of chemotherapy or maintenance regimens.
How does tioguanine work?+
Tioguanine is a purine analog that is incorporated into DNA during the S‑phase of cell division. This incorporation disrupts normal base pairing, leading to faulty DNA synthesis and triggering apoptosis in rapidly dividing cells such as malignant lymphoblasts, myeloid cells, and immune cells involved in graft rejection.
What is the usual dose of Lanvis?+
The dosage of Lanvis is individualized by the treating physician based on the specific indication, patient weight, renal and hepatic function, and concurrent therapies. Prescribers calculate the appropriate amount and schedule, and the medication is supplied in tablet form for oral administration according to that professional guidance.
Is Lanvis safe in pregnancy or breastfeeding?+
Safety data for tioguanine during pregnancy and lactation are limited. Because the drug can affect rapidly dividing fetal cells and may be excreted in breast milk, it is generally avoided unless the potential benefit outweighs the risk. Decisions should be made by the prescribing clinician in consultation with the patient.
How do I order Lanvis from GNH USA?+
To place an order, submit an enquiry on the Lanvis product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lanvis compare with other immunosuppressants?+
Lanvis (tioguanine) belongs to the purine analog class, whereas alternatives such as azathioprine or mycophenolate mofetil are also antimetabolites but differ in metabolic activation and toxicity profiles. Tioguanine tends to have a higher risk of hepatic toxicity, while azathioprine may cause more pronounced bone‑marrow suppression. Choice depends on disease, tolerance and physician experience.
How should Lanvis be stored and handled?+
Lanvis tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discolored. No special refrigeration is required.
How is Lanvis administered?+
Lanvis is taken orally, usually with a glass of water. The tablets can be swallowed whole or, if necessary, divided according to the prescriber’s instructions. Administration should follow the dosing schedule set by the healthcare provider, and patients should adhere to any dietary or timing recommendations to optimize absorption and minimize gastrointestinal irritation.
What are the most serious risks associated with Lanvis?+
The most serious adverse events linked to tioguanine include severe bone‑marrow suppression (neutropenia, thrombocytopenia, anemia), hepatotoxicity that can progress to liver failure, opportunistic infections due to immunosuppression, and, rarely, secondary malignancies. Patients should be monitored closely with regular blood counts and liver function tests to detect these complications early.
Who should not use Lanvis?+
Lanvis is contraindicated in patients with known hypersensitivity to tioguanine or other purine analogs, those with active severe infections, and individuals with significant hepatic or renal impairment that cannot be corrected. It should also be avoided in pregnant women unless absolutely necessary, and in patients receiving other myelosuppressive agents without careful monitoring. Clinicians must evaluate each patient’s medical history before prescribing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tioguanine
Route
Oral Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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