GNH USA

Europe — EMA

Lanvis (Tioguanine)

GNH USA supplies Lanvis (Tioguanine), an immunosuppressant for acute myeloid leukemia, chronic myelogenous leukemia and inflammatory bowel disease.

Tioguanine

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What is Tioguanine?

Tioguanine, the active ingredient in Lanvis, is a thiopurine antimetabolite presented as an oral tablet for systemic use. It is employed in the treatment of certain leukemias and inflammatory bowel disease.

GNH USA supplies Lanvis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

What is Tioguanine used for?

Lanvis is a thiopurine antimetabolite that acts on rapidly dividing cells in hematologic malignancies and immune‑mediated disorders.

Acute myeloid leukemia: used as part of induction or consolidation therapy to reduce leukemic cell proliferation. Chronic myelogenous leukemia: incorporated into treatment regimens to achieve cytoreduction. Inflammatory bowel disease: employed to maintain remission by suppressing immune activity.

What are the side effects of Tioguanine?

Adverse reactions may occur with Tioguanine therapy and should be monitored.

Common Side Effects: - Nausea or vomiting - Diarrhea or abdominal discomfort - Fatigue or lethargy - Mild leukopenia or neutropenia - Rash or mild skin irritation - Elevated liver enzymes

Serious or Rare Side Effects: - Severe bone‑marrow suppression (pancytopenia) - Hepatotoxicity or hepatic failure - Life‑threatening infections - Pancreatitis - Secondary malignancies - Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)

What precautions apply to Tioguanine?

Tioguanine requires careful monitoring and patient education before and during therapy. - Blood count monitoring: regular CBC to detect leukopenia or anemia. - Liver function: periodic LFTs to identify hepatotoxicity. - Infection risk: avoid use in patients with active severe infections. - Dose adjustment: consider renal or hepatic impairment when dosing. - Pregnancy and lactation: safety not established; use only if benefits outweigh risks. - Storage: Store below 25°C: keep in the original container, protect from moisture and light.

What does Tioguanine interact with?

Tioguanine may interact with several medicines, altering its efficacy or toxicity.

Major Interactions (Avoid): - Allopurinol or other xanthine oxidase inhibitors: can markedly increase thioguanine toxicity. - Azathioprine: additive myelosuppression risk. - Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of gastrointestinal irritation. - Sulfonamide antibiotics: potential for additive bone‑marrow suppression. - Antiviral agents (e.g., acyclovir): may affect hepatic metabolism. - Methotrexate: combined immunosuppression may require closer monitoring.

Frequently asked questions

What conditions is Lanvis (Tioguanine) used to treat?+
Lanvis contains Tioguanine, which is indicated for the treatment of acute myeloid leukemia, chronic myelogenous leukemia, and inflammatory bowel disease. In each case the drug helps to suppress abnormal cell proliferation or immune activity.
How does Tioguanine work in the body?+
Tioguanine is converted inside cells to thioguanine nucleotides. These metabolites block purine synthesis and become incorporated into DNA and RNA, disrupting nucleic‑acid function and leading to the death of rapidly dividing malignant or immune cells.
What is the usual dose of Lanvis?+
The specific dose of Lanvis is determined by the prescribing clinician based on the patient’s diagnosis, disease severity, laboratory values and overall health. Dosing is individualized and should follow the prescriber’s instructions.
Is Lanvis safe to use during pregnancy or breastfeeding?+
Safety of Tioguanine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and this decision must be made by the treating physician.
How do I order Lanvis from GNH USA?+
To request Lanvis, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lanvis compare with other thiopurine drugs?+
Lanvis (Tioguanine) belongs to the thiopurine class, similar to azathioprine and mercaptopurine. While all share a common mechanism of inhibiting purine synthesis, Tioguanine is often used when a more direct thioguanine nucleotide formation is desired, and dosing or toxicity profiles may differ.
What are the recommended storage conditions for Lanvis?+
Lanvis should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keeping the product in a dry, cool environment helps maintain its stability and potency.
How is Lanvis administered to patients?+
Lanvis is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule (e.g., daily or intermittent) is individualized based on the therapeutic indication and patient response.
What are the most serious risks associated with Lanvis?+
The most serious risks include severe bone‑marrow suppression (pancytopenia), hepatotoxicity, life‑threatening infections, pancreatitis and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for these events.
Who should not take Lanvis?+
Lanvis is contraindicated in patients with known hypersensitivity to Tioguanine or any excipients, those with active severe infections, and individuals for whom the risk of immunosuppression outweighs the therapeutic benefit. The prescriber must evaluate each patient’s suitability.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tioguanine
Route
Oral Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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