GNH USA

Europe — EMA

Lanvis

GNH USA supplies Lanvis (Tioguanine), a purine analog for acute lymphoblastic leukemia, chronic myeloid leukemia and inflammatory bowel disease.

Tioguanine

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What is Tioguanine?

Tioguanine, the active ingredient in Lanvis, is a purine analog presented as an oral formulation for oral use. It is employed in the treatment of certain leukemias and inflammatory bowel disease, targeting rapidly dividing cells in affected patients across populations worldwide.

GNH USA supplies Lanvis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics for global healthcare providers, ensuring consistent product availability across regions.

What is Tioguanine used for?

Lanvis (tioguanine) is used in hematologic malignancies and certain inflammatory conditions.

Acute lymphoblastic leukemia: helps achieve remission by inhibiting leukemic cell proliferation. Chronic myeloid leukemia: contributes to disease control through cytotoxic effects on malignant clones. Inflammatory bowel disease: reduces intestinal inflammation by suppressing overactive immune cell replication.

What are the side effects of Tioguanine?

Tioguanine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea and vomiting - Diarrhea - Myelosuppression (e.g., neutropenia, anemia) - Alopecia and fatigue

Serious or Rare Side Effects: - Severe bone marrow suppression - Hepatic toxicity - Secondary malignancies - Severe infections and hypersensitivity reactions

What precautions apply to Tioguanine?

When using Lanvis, careful monitoring and patient counseling are essential. - Blood count monitoring: perform regular complete blood counts to detect myelosuppression. - Liver function monitoring: assess hepatic enzymes periodically. - Renal function: adjust use in severe renal impairment. - Pregnancy and lactation: use only if benefits outweigh unknown risks. - Concomitant myelosuppressive agents: avoid or use with caution. - Store below 25°C: keep in the original pack, protect from moisture.

What does Tioguanine interact with?

Tioguanine interacts with several medicines; some combinations should be avoided while others require close observation.

Major Interactions (Avoid): - Concurrent use with other antimetabolites (e.g., azathioprine): may cause additive myelosuppression. - Allopurinol: can increase tioguanine toxicity. - Live vaccines: risk of severe infection due to immunosuppression.

Moderate Interactions (Monitor Closely): - Antibiotics such as sulfonamides: may enhance bone marrow suppression. - NSAIDs: may increase risk of gastrointestinal irritation. - Antifungal agents (e.g., fluconazole): may alter metabolism.

Frequently asked questions

What is Lanvis used for?+
Lanvis contains tioguanine and is indicated for the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and inflammatory bowel disease. In each condition it works by interfering with the replication of rapidly dividing cells, helping to achieve disease control or remission as part of a broader therapeutic regimen.
How does tioguanine work?+
Tioguanine is converted inside cells to thioguanine nucleotides, which are falsely incorporated into DNA and RNA. This incorporation disrupts normal nucleic acid synthesis, leading to faulty replication and triggering programmed cell death, especially in fast‑growing lymphoid and myeloid cells that drive the targeted diseases.
What is the usual dose of Lanvis?+
The dose of Lanvis is individualized. The prescribing clinician determines the appropriate amount based on the specific indication, patient weight, renal and hepatic function, and ongoing laboratory monitoring. No standard dose can be provided without a qualified medical assessment.
Is Lanvis safe in pregnancy or breastfeeding?+
Safety data for tioguanine during pregnancy and lactation are limited. Because the drug can affect rapidly dividing cells, it may pose risks to the fetus or nursing infant. Use is only recommended when the potential therapeutic benefit outweighs the uncertain risks, and it should be decided by a qualified healthcare professional.
How do I order Lanvis from GNH USA?+
To request Lanvis, visit the product page on gnh-usa.com and submit an enquiry with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.
How does Lanvis compare with other antineoplastic agents?+
Lanvis (tioguanine) belongs to the purine analog class, similar to mercaptopurine. Both drugs interfere with nucleic acid synthesis, but tioguanine often has a longer intracellular half‑life, which can allow less frequent dosing in some protocols. Choice between them depends on disease specifics, patient tolerance, and physician experience.
What are the storage and handling requirements for Lanvis?+
Lanvis should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product in a dry area and avoid exposure to high humidity. No refrigeration is required for this oral formulation.
How is Lanvis administered?+
Lanvis is taken orally, usually with a glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal discomfort. The exact schedule—once daily or divided doses—depends on the prescribing clinician’s instructions.
What are the most serious risks associated with Lanvis?+
The most serious adverse risks include severe bone‑marrow suppression leading to infections, anemia or bleeding; hepatic toxicity that can progress to liver failure; and the rare possibility of secondary malignancies. Patients should be monitored regularly for blood counts and liver function to detect these complications early.
Who should not use Lanvis?+
Lanvis is contraindicated in patients with known hypersensitivity to tioguanine or any excipients, in those with severe hepatic impairment, and in individuals where the risk of immunosuppression outweighs benefit, such as untreated active infections. Pregnant women should only use it when clearly indicated by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tioguanine
Route
Oral Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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