GNH USA

Europe — EMA

Lanvis (Tioguanine)

GNH USA supplies Lanvis (Tioguanine), a thiopurine immunosuppressant for acute lymphoblastic leukemia and inflammatory bowel disease. Request a quote.

Tioguanine

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What is Tioguanine?

Tioguanine, the active ingredient in Lanvis, is a thiopurine presented as an oral tablet for oral use. It is employed as an immunosuppressant in the treatment of certain leukemias and inflammatory bowel disease, targeting rapidly dividing cells in affected patients. GNH USA supplies Lanvis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Tioguanine used for?

Lanvis (tioguanine) is used in diseases where abnormal proliferation of lymphoid or myeloid cells occurs, or where immune modulation is required. Acute lymphoblastic leukemia: helps achieve remission by inhibiting malignant lymphoblast proliferation. Chronic myeloid leukemia: contributes to disease control when used in combination regimens. Inflammatory bowel disease: reduces inflammatory activity and maintains remission in ulcerative colitis or Crohn's disease.

What are the side effects of Tioguanine?

Adverse reactions may occur with tioguanine therapy and should be monitored.

Common Side Effects: - Nausea or vomiting - Diarrhoea - Mild rash or skin irritation - Transient elevation of liver enzymes - Decreased white blood cell count (leukopenia)

Serious or Rare Side Effects: - Severe bone‑marrow suppression leading to pancytopenia - Life‑threatening infections due to immunosuppression - Hepatic toxicity or jaundice - Acute pancreatitis - Secondary malignancies such as lymphomas - Severe hypersensitivity reactions including Stevens‑Johnson syndrome

What precautions apply to Tioguanine?

Tioguanine requires careful monitoring and patient education before and during therapy. Monitor blood counts regularly: detect early bone‑marrow suppression. Assess liver function: watch for hepatotoxicity. Avoid use in patients with known hypersensitivity to thiopurines. Use caution in renal impairment: dose adjustment may be needed. Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Tioguanine interact with?

Tioguanine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Azathioprine: additive immunosuppression increases risk of severe cytopenias. - Allopurinol: can markedly raise tioguanine levels, leading to toxicity. - Warfarin: may enhance anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Methotrexate: combined myelosuppression requires frequent blood‑count checks. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase gastrointestinal irritation. - Trimethoprim‑sulfamethoxazole: can potentiate bone‑marrow suppression.

Frequently asked questions

What conditions is Lanvis (tioguanine) used for?+
Lanvis contains tioguanine and is indicated for the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and inflammatory bowel disease such as ulcerative colitis or Crohn's disease. In each case it helps control abnormal cell growth or modulate the immune response as part of a prescribed therapeutic regimen.
How does tioguanine work in the body?+
Tioguanine is converted inside cells to thioguanine nucleotides, which become incorporated into DNA and RNA. This fraudulent incorporation interferes with nucleic‑acid synthesis, leading to reduced replication of rapidly dividing cells, especially malignant lymphoid or myeloid cells, and produces an overall immunosuppressive effect.
What is the usual dose of Lanvis?+
The dose of Lanvis is individualized by the treating physician based on the specific indication, patient weight, renal and hepatic function, and response to therapy. Only a qualified prescriber can determine the appropriate dosing schedule and any necessary adjustments.
Is Lanvis safe to use during pregnancy or breastfeeding?+
Safety data for tioguanine in pregnancy and lactation are limited. The drug may cross the placenta and be excreted in breast milk, potentially affecting the fetus or infant. Use only if the potential benefit justifies the potential risk, and discuss alternatives with a healthcare professional.
How do I order Lanvis from GNH USA?+
To place an order, submit an enquiry on the Lanvis product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.
How does Lanvis compare with other thiopurines such as azathioprine?+
Both tioguanine (Lanvis) and azathioprine belong to the thiopurine class and share a similar mechanism of incorporating fraudulent nucleotides into DNA/RNA. Tioguanine is often used when azathioprine is ineffective or not tolerated, but both require careful monitoring for bone‑marrow suppression and liver toxicity. Choice depends on clinical response, tolerability and physician preference.
What are the recommended storage conditions for Lanvis?+
Lanvis should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product away from excessive heat and humidity, and ensure the container is tightly closed when not in use.
How is Lanvis administered to patients?+
Lanvis is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and frequency depend on the individual treatment plan, and patients should follow the dosing instructions provided by their healthcare professional.
What are the most serious risks associated with Lanvis therapy?+
The most serious risks include severe bone‑marrow suppression leading to pancytopenia, life‑threatening infections due to immunosuppression, hepatic toxicity, pancreatitis, and rare but severe hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for signs of infection, abnormal blood counts, or liver dysfunction.
Who should not use Lanvis?+
Lanvis is contraindicated in patients with known hypersensitivity to tioguanine or other thiopurines, in those with severe hepatic impairment, and in individuals with active, uncontrolled infections. Caution is also advised for patients with significant renal dysfunction, pregnant or breastfeeding women, and anyone taking interacting medications without appropriate monitoring.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tioguanine
Route
Oral Use
Manufacturer
Aspen Pharma Trading Limited
Origin
EU

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