Lacipil

Lacidipine, the active ingredient in Lacipil, is a calcium channel blocker presented as a tablet for oral use. It is used to treat hypertension in adult patients requiring blood pressure control.

GNH USA supplies Lacipil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lacidipine is a dihydropyridine calcium channel blocker indicated for the management of high blood pressure.

- Essential hypertension: reduces systolic and diastolic pressure in patients with primary hypertension. - Isolated systolic hypertension: lowers elevated systolic readings, especially in older adults. - Hypertension with coronary artery disease: provides blood pressure control while improving coronary perfusion.

Lacidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Headache: mild to moderate pain often occurring early in therapy. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of ankles or feet due to fluid accumulation. - Dizziness: sensation of light‑headedness, especially when standing. - Nausea: mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Angioedema: swelling of face, lips, tongue, or throat that may compromise airway. - Myocardial infarction: rare occurrence of heart attack. - Elevated liver enzymes: indication of hepatic stress. - Severe bradycardia: unusually low heart rate. - Allergic reactions: rash, itching, or anaphylaxis.

Before initiating Lacidipine therapy, consider the following safety measures.

- Blood pressure monitoring: regularly assess to avoid excessive hypotension. - Hepatic function: evaluate liver enzymes in patients with liver disease. - Elderly patients: start at lower doses and monitor for dizziness. - Concomitant antihypertensives: adjust doses to prevent additive effects. - Severe aortic stenosis: contraindicated due to risk of reflex tachycardia. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Lacidipine can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase Lacidipine plasma levels. - Other potent vasodilators: risk of additive hypotension. - Grapefruit juice: can raise drug concentration leading to toxicity.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect. - Diuretics: may enhance blood pressure lowering. - Beta‑blockers: monitor for excessive heart rate reduction. - NSAIDs: may blunt antihypertensive response.