Lacidipin Teva

Lacidipine, the active ingredient in Lacidipin, is a calcium channel blocker presented as an oral tablet for systemic use. It lowers elevated blood pressure by relaxing vascular smooth muscle and is prescribed for adults with hypertension and is commonly used in clinical practice to achieve target blood pressure levels. The drug is absorbed after ingestion and reaches peak plasma concentrations within a few hours.

GNH USA supplies Lacidipin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lacidipine is indicated for the management of hypertension, a condition characterized by chronically elevated arterial pressure.

Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension. Isolated systolic hypertension: helps lower high systolic readings in elderly patients. Secondary hypertension: assists in controlling blood pressure when caused by underlying disorders.

Lacidipine may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects: - Headache: mild to moderate headache reported. - Flushing: transient facial flushing. - Dizziness: sensation of light‑headedness. - Peripheral edema: swelling of ankles or lower limbs. - Nausea: occasional upset stomach. - Tachycardia: increased heart rate.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Myocardial infarction: rare occurrence of heart attack. - Hepatic dysfunction: elevated liver enzymes. - Angioedema: swelling of face, lips, or airway. - Severe allergic reaction: rash, itching, or anaphylaxis. - Cardiac arrhythmia: irregular heart rhythm.

When prescribing lacidipine, clinicians should observe several safety considerations.

- Monitor blood pressure: adjust dose based on therapeutic response. - Assess hepatic function: use caution in patients with liver impairment. - Caution in elderly: increased sensitivity to hypotensive effects. - Avoid abrupt discontinuation: taper to prevent rebound hypertension. - Use with caution in heart failure: may exacerbate symptoms. - Store at room temperature: keep in original packaging, protect from moisture and light.

Lacidipine can interact with other medicines, influencing its plasma levels or blood‑pressure effects.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise lacidipine concentrations. - Grapefruit juice: can increase drug exposure and risk of hypotension. - Co‑administration with other calcium‑channel blockers (e.g., verapamil): additive vasodilatory effect.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce lacidipine efficacy. - Diuretics (e.g., thiazides): may enhance blood‑pressure lowering, requiring dose adjustment.