Lacidipine Zentiva Pharma Limited

Lacidipine, the active ingredient in Lacidipine Zentiva Pharma Limited, is a calcium channel blocker presented as an oral tablet for oral administration. It is indicated for the management of hypertension in adult patients, helping to reduce elevated systolic and diastolic blood pressure.

GNH USA supplies Lacidipine Zentiva Pharma Limited as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution channels that meet EU regulatory standards. The company ensures product integrity through rigorous quality control and temperature‑controlled logistics.

Lacidipine is a calcium channel blocker used in the management of hypertension. - Hypertension: lowers both systolic and diastolic blood pressure in adult patients. - Essential hypertension: provides long‑term control of elevated blood pressure when lifestyle measures are insufficient. - Isolated systolic hypertension: reduces high systolic pressure, particularly in older adults.

Lacidipine may cause adverse reactions; reported events are categorized by frequency.

Common Side Effects: - Headache: mild to moderate pain often occurring early in therapy. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of the lower extremities. - Dizziness: sensation of light‑headedness, especially upon standing.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Angioedema: rapid swelling of face, lips, tongue or airway. - Hepatic dysfunction: abnormal liver enzyme elevations or hepatitis.

Before initiating Lacidipine, consider the following precautions to ensure safe use. - Monitor blood pressure: adjust dose based on therapeutic response. - Assess liver function: evaluate hepatic enzymes prior to treatment. - Caution in elderly: start at lower dose due to increased sensitivity. - Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension. - Use with caution in heart failure: may exacerbate symptoms. - Store at room temperature: keep in original packaging, protect from moisture.

Lacidipine can interact with other medicines; awareness of major and moderate interactions helps prevent adverse effects.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase Lacidipine plasma levels. - Concomitant antihypertensives causing additive hypotension: risk of excessive blood pressure drop. - Grapefruit juice: can elevate drug concentration and enhance effects.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy. - Diuretics: may enhance hypotensive effect, requiring dose adjustment. - Beta‑blockers: combined use may increase risk of bradycardia.