GNH USA

Europe — EMA

Izoprenalin Macure

GNH USA supplies Izoprenalin Macure (Isoprenaline Hydrochloride), a beta‑adrenergic agonist for symptomatic bradycardia, heart block and bronchospasm.

Isoprenaline Hydrochloride

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What is Isoprenaline Hydrochloride?

Isoprenaline Hydrochloride, the active ingredient in Izoprenalin Macure, is a beta‑adrenergic agonist presented as an injection solution for intravenous use. It treats symptomatic bradycardia, heart block, cardiac arrest, and bronchospasm in acute care settings.

GNH USA supplies Izoprenalin Macure as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Isoprenaline Hydrochloride used for?

Isoprenaline Hydrochloride is a non‑selective beta‑adrenergic agonist used in acute cardiac and respiratory conditions. - Symptomatic bradycardia: increases heart rate to alleviate slow heart rhythms. - Heart block: improves atrioventricular conduction by enhancing myocardial contractility. - Cardiac arrest: provides temporary circulatory support during resuscitation efforts. - Bronchospasm / asthma: relaxes bronchial smooth muscle to improve airflow.

What are the side effects of Isoprenaline Hydrochloride?

Isoprenaline Hydrochloride may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Tachycardia: rapid heart rate. - Palpitations: awareness of heartbeat. - Tremor: fine muscle shaking. - Nausea: upset stomach.

Serious or Rare Side Effects: - Arrhythmias: potentially life‑threatening irregular rhythms. - Myocardial ischemia: reduced blood flow to heart muscle. - Severe hypotension: dangerously low blood pressure.

What precautions apply to Isoprenaline Hydrochloride?

Use of Izoprenalin Macure requires careful clinical monitoring and consideration of patient‑specific factors. - Cardiovascular monitoring: observe heart rate and blood pressure continuously during infusion. - Use with caution in coronary artery disease: risk of myocardial ischemia. - Avoid in uncontrolled hypertension: may exacerbate high blood pressure. - Monitor electrolyte levels: hypokalemia can increase arrhythmia risk. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Isoprenaline Hydrochloride interact with?

Isoprenaline Hydrochloride can interact with several drug classes, influencing its efficacy and safety.

Major Interactions (Avoid): - Beta‑blockers: antagonize isoprenaline effects, reducing therapeutic benefit. - Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive responses. - Tricyclic antidepressants: increase risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely): - Digitalis glycosides: additive increase in heart rate. - Diuretics causing electrolyte imbalance: heightened arrhythmia risk. - Theophylline: may amplify bronchodilator effect, monitor for tachycardia.

Frequently asked questions

What is Izoprenalin Macure used for?+
Izoprenalin Macure contains isoprenaline hydrochloride and is used in emergency settings to treat symptomatic bradycardia, heart block, cardiac arrest, and bronchospasm. By stimulating beta‑adrenergic receptors, it raises heart rate, improves cardiac contractility, and relaxes airway smooth muscle, providing rapid physiological support when conventional measures are insufficient.
How does Isoprenaline Hydrochloride work?+
Isoprenaline Hydrochloride is a non‑selective beta‑adrenergic agonist. It binds to β1 receptors in the heart, increasing cyclic AMP and producing faster heartbeats and stronger contractions. Simultaneously, it activates β2 receptors in the lungs, causing smooth‑muscle relaxation and bronchodilation. The combined actions enhance cardiac output and airway patency during acute crises.
What is the usual dose of Izoprenalin Macure?+
The specific dose of Izoprenalin Macure is determined by the prescribing clinician based on the patient’s condition, weight, and response. Dosing is individualized and administered intravenously, often as a continuous infusion or titrated bolus under continuous cardiac and respiratory monitoring.
Is Izoprenalin Macure safe in pregnancy or breastfeeding?+
Safety data for isoprenaline hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians must evaluate each case carefully and consider alternative therapies when appropriate.
How do I order Izoprenalin Macure from GNH USA?+
To order Izoprenalin Macure, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.
How does Izoprenalin Macure compare with the main alternative drug or class?+
The primary alternatives to isoprenaline are dopamine and epinephrine. While dopamine has dose‑dependent effects on dopaminergic and adrenergic receptors, epinephrine stimulates both alpha and beta receptors, causing vasoconstriction as well as cardiac stimulation. Isoprenaline offers a more selective beta‑agonist profile, providing strong chronotropic and bronchodilator effects with less peripheral vasoconstriction, which can be advantageous in certain cardiac or respiratory emergencies.
What are the storage and handling requirements for Izoprenalin Macure?+
Izoprenalin Macure should be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If the product reaches room temperature, it should be used promptly and not re‑refrigerated.
How is Izoprenalin Macure given or administered?+
The medication is supplied as a sterile injection solution for intravenous use. It can be administered as a slow intravenous bolus or as a continuous infusion, depending on the clinical situation. Administration should occur under continuous cardiac and respiratory monitoring, with dosage adjustments made by the treating physician.
What are the most serious risks to watch for when using Izoprenalin Macure?+
Serious risks include life‑threatening arrhythmias, myocardial ischemia, and severe hypotension. Patients may also develop excessive tachycardia or experience allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these events occur, and continuous monitoring is essential during therapy.
Who should not use Izoprenalin Macure?+
Izoprenalin Macure is contraindicated in patients with known hypersensitivity to isoprenaline or any component of the formulation. It should be avoided in individuals with uncontrolled hypertension, severe coronary artery disease, or recent myocardial infarction unless the benefits clearly outweigh the risks and close monitoring is possible.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Isoprenaline Hydrochloride
Route
Intravenous Use
Manufacturer
Macure Pharma Aps
Origin
EU

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